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首页> 外文期刊>Infection and immunity >Immunological relationship between delta herpesvirus of patas monkeys and varicells-zoster virus of humans.
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Immunological relationship between delta herpesvirus of patas monkeys and varicells-zoster virus of humans.

机译：帕塔斯猴三角洲疱疹病毒与人类水痘带状疱疹病毒之间的免疫学关系。

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摘要

The Delta herpesvirus (DHV) which produced outbreaks of exanthematous disease in patas monkeys was shown to have a close immunological relationship to varicella-zoster (V-Z) virus of man. Immunization of rhesus monkeys with DHV or V-Z virus resulted in the development of neutralizing antibodies to both viruses and also in the production of complement-fixing antibodies to V-Z virus. Immunoglobulin M neutralizing antibody to V-Z virus was demonstrated in the serum of a rhesus monkey immunized with DHV, suggesting a primary antibody response rather than recall of antibody to a related virus. Convalescent-phase sera from human zoster cases had comparable levels of neutralizing antibody for both DHV and V-Z virus. Patas monkeys involved in an outbreak of DHV infection showed seroconversion to both DHV and V-Z virus by neutralization tests and to V-Z virus by complement fixation tests. The demonstration of the close antigneic relationship between DHV and V-Z virus suggests that DHV may be useful in an animal model system for studies on the latency and reactivation of V-Z virus.
机译：三角洲疱疹病毒（DHV）在帕塔斯猴中引起爆发发炎，被证明与人的水痘-带状疱疹（V-Z）病毒具有密切的免疫学关系。用DHV或V-Z病毒免疫恒河猴导致了针对这两种病毒的中和抗体的发展，也导致了针对V-Z病毒的补体固定抗体的产生。在用DHV免疫的恒河猴的血清中证实了针对V-Z病毒的免疫球蛋白M中和抗体，表明是初级抗体反应，而不是针对相关病毒的抗体召回。人带状疱疹病例的恢复期血清对DHV和V-Z病毒的中和抗体水平相当。参与DHV感染暴发的Patas猴子通过中和测试显示血清转化为DHV和V-Z病毒，通过补体固定测试显示血清转化为V-Z病毒。 DHV和V-Z病毒之间密切的消血脂关系的证明表明，DHV在动物模型系统中可能对研究V-Z病毒的潜伏期和再激活有用。

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