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Growth of Mycobacterium lepraemurinum in the mouse bone marrow: an ultrastructural study.

机译:小鼠骨髓中分枝杆菌的生长:超微结构研究。

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The ultrastruct of the mouse bone marrow during the first 8 weeks after intravenous inoculation of animals with 10(9) Mycobacterium lepraemurium is described. The bacteria were almost exclusively in macrophages, which became converted to epithelioid cells after 8 weeks, at which time they were very heavily infected. The nature of the exceptionally rapid increase in numbers of bacteria in the bone marrow compared with other tissues early in the infection is discussed. It is concluded that a short doubling time of bacteria situated in the marrow is a more probable explanation than recruitment from elsewhere in the animal.
机译:描述了用10(9)麻风分枝杆菌静脉内接种动物后的最初8周内小鼠骨髓的超微结构。该细菌几乎完全位于巨噬细胞中,在8周后被转化为上皮样细胞,这时它们受到了严重感染。讨论了与感染初期的其他组织相比,骨髓中细菌数量异常迅速增加的性质。结论是,与从动物其他地方募集相比,位于骨髓中的细菌短时间加倍是更可能的解释。

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