Interactions of radio-detoxified Escherichia coli endotoxin preparations with the complement system.

G Füst; L Bertók; S Juhász-Nagy

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Interactions of radio-detoxified Escherichia coli endotoxin preparations with the complement system.

机译：放射性解毒的大肠杆菌内毒素制剂与补体系统的相互作用。

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Escherichia coli O89 lipopolysaccharide (LPS) was treated with different doses of gamma irradiation (5, 10, 15, and 20 Mrad). Various biological activities such as lethal effect, decrease in arterial blood pressure in dogs, and interaction with the complement system were determined for the parent and irradiated preparations. Irradiation of LPS significantly and in a dose-dependent manner decreased its lethal and blood pressure-depressing effects along with its ability to activate the complement system. In contrast, radio-detoxified LPS fixed more strongly the isolated human C1 than did the parent LPS. The possible connection between the toxicity of endotoxin and endotoxin-induced complement activation is discussed.

机译：用不同剂量的γ射线（5、10、15和20 Mrad）处理大肠杆菌O89脂多糖（LPS）。确定了母体和辐照制剂的各种生物活性，如致死作用，狗动脉血压的降低以及与补体系统的相互作用。 LPS的辐射显着并以剂量依赖的方式降低了其致死和降低血压的作用，以及激活补体系统的能力。相比之下，经放射性排毒的LPS固定的分离的人C1比亲本LPS更牢固。讨论了内毒素毒性和内毒素诱导的补体激活之间的可能联系。

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《Infection and immunity》 |1977年第1期|共6页
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G Füst; L Bertók; S Juhász-Nagy;
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中图分类医学免疫学;
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6. Interactions of radio-detoxified Escherichia coli endotoxin preparations with the complement system. [O] . G Füst, L Bertók, S Juhász-Nagy 1977

机译：放射性解毒的大肠杆菌内毒素制剂与补体系统的相互作用。
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8. Interaction of Ionizing Radiation and E. Coli Endotoxin. I. Effect of Radiation on Endotoxin Shock [R] . Vick, J. A., Ciuchta, H. P., Berdjis, C. C. 1966

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Interactions of radio-detoxified Escherichia coli endotoxin preparations with the complement system.

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