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首页> 外文期刊>Infection and immunity >Mechanisms and Genetics of Resistance to Sodium Lauryl Sulfate in Strains of Shigella and Escherichia coli
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Mechanisms and Genetics of Resistance to Sodium Lauryl Sulfate in Strains of Shigella and Escherichia coli

机译：志贺氏菌和大肠杆菌对月桂基硫酸钠的抗性机理和遗传

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摘要

The sensitivity to sodium lauryl sulfate (SLS) of Shigella flexneri and Escherichia coli is determined by at least three genes. One site is located near the lactose operon, and two loci are cotransducible with the arabinose operon. Calcium ions protect against SLS lysis. One gene is concerned with the relative ability of the bacterium to retain calcium against such chelating agents as ethylenediaminetetraacetic acid or phosphate buffer. This was first observed in a mutation from virulence to avirulence in S. flexneri with a concomitant loss of ability to penetrate the intestinal epithelium. The avirulent strain is far less sensitive to lysis by SLS in the presence of phosphate buffer than its virulent parent. The avirulent strain is also less sensitive to lysozyme and ethylenediaminetetraacetic acid. E. coli K-12 is much more sensitive to SLS than both of these Shigella strains. An E. coli-S. flexneri hybrid, which is unable to survive well in the gut and thus only produces an abortive infection, has inherited this extreme sensitivity to SLS.
机译：至少有三个基因决定了弗氏志贺氏菌和大肠杆菌对月桂基硫酸钠的敏感性。一个位点位于乳糖操纵子附近，并且两个位点可与阿拉伯糖操纵子共转导。钙离子可防止SLS裂解。一个基因与细菌相对于诸如乙二胺四乙酸或磷酸盐缓冲液之类的螯合剂保留钙的相对能力有关。这首先在 S中从毒力到无毒力的突变中观察到。 flexneri 伴随着肠上皮穿透能力的丧失。在有磷酸盐缓冲液的情况下，无毒力菌株对SLS裂解的敏感性远低于其有毒力的亲本。无毒菌株对溶菌酶和乙二胺四乙酸的敏感性也较低。 E。大肠杆菌 K-12对SLS的敏感性要比这两个 Shigella 菌株都高。 大肠杆菌。 flexneri 杂种不能在肠道中很好地存活，因此只能产生流产感染，已经继承了这种对SLS的极端敏感性。

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