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Cross-Protection in Hamsters Immunized with Group A Arbovirus Vaccines

机译：用A组虫媒病毒疫苗免疫的仓鼠中的交叉保护

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Cross-protection between Venezuelan, Eastern, and Western equine encephalomyelitis (VEE, EEE, WEE) viruses was studied in the hamster by using challenge responses and neutralizing antibody titers as indexes of protection. Formalin-inactivated vaccines induced only homologous protection regardless of the sequence of vaccination or the combination of vaccines employed. Use of attenuated VEE vaccine, singly, produced absolute homologous protection as well as 37 and 59% protection against WEE and EEE challenges, respectively. Neither deleterious nor enhancing interaction occurred when attenuated VEE and inactivated WEE and EEE vaccines were employed in various sequences of immunization and all possible combinations. The most rapid and simple immunization scheme eliciting excellent homologous protection consisted of a single dose of combined attenuated VEE and inactivated WEE and EEE vaccines. Studies with attenuated strains of VEE, EEE, and WEE viruses showed that all elicited excellent homologous protection when administered singly. However, use of these live strains in many combinations and sequences resulted in a significant (P < 0.05 to <0.001) decrease in the protective efficacy of the WEE or EEE strains. These results are discussed in relation to serum neutralization test data obtained on sera drawn pre- and postchallenge.
机译：委内瑞拉，东部和西部马脑脊髓炎病毒（VEE，EEE，WEE）病毒之间的交叉保护通过使用攻击反应和中和抗体效价作为保护指标在仓鼠中进行了研究。福尔马林灭活的疫苗仅诱导同源保护，而与疫苗接种的顺序或所用疫苗的组合无关。单独使用减毒VEE疫苗可产生绝对的同源保护，并分别对WEE和EEE产生37％和59％的保护。当在各种免疫顺序和所有可能的组合中使用减毒VEE和灭活的WEE和EEE疫苗时，既没有有害的相互作用也没有增强的相互作用。引起极好的同源保护的最快速，最简单的免疫方案包括单剂减毒的VEE疫苗和灭活的WEE和EEE疫苗。对VEE，EEE和WEE病毒的减毒株进行的研究表明，单独给药时，所有病毒均可引起出色的同源保护。但是，以多种组合和顺序使用这些活菌株会导致WEE或EEE菌株的保护功效显着降低（ P <0.05至<0.001）。结合在攻击前和攻击后血清中获得的血清中和测试数据讨论了这些结果。

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