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首页> 外文期刊>Infection and immunity >Lytic and Turbid Plaque-Type Mutants of Lymphocytic Choriomeningitis Virus as a Cause of Neurological Disease or Persistent Infection
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Lytic and Turbid Plaque-Type Mutants of Lymphocytic Choriomeningitis Virus as a Cause of Neurological Disease or Persistent Infection

机译：淋巴细胞性脉络膜脑膜炎病毒的溶质和浑浊噬菌斑型突变体是神经疾病或持续感染的原因

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Mouse-passaged lymphocytic choriomeningitis (LCM) virus was found to contain a mixture of two different plaque-type mutants when plated on BHK-21/13S cells in agarose suspension. One mutant gave rise to clear plaques, with death of the cells, whereas the other produced turbid plaques which were sometimes very difficult to see. The clear-plaque variant caused a pronounced cytopathic effect on BHK-21 cells, but the turbid variant caused none; it also interfered with the cytopathic effect due to the clear variant. Brain-passed LCM virus was found to consist mainly of the clear-plaque-type, whereas liver-passed virus was mainly turbid-plaque-type. The clear type induced convulsions and early death after intracerebral inoculation of adult mice; the turbid variant caused no convulsions and late deaths. In newborn mice, the clear-plaque-type was uniformly fatal, whereas the turbid variant caused no deaths but instead induced persistent tolerant infection.
机译：当将小鼠传代淋巴细胞脉络膜脑膜炎（LCM）病毒涂在琼脂糖悬浮液中的BHK-21 / 13S细胞上时，含有两种不同噬斑型突变体的混合物。一个突变体产生清晰的噬菌斑，导致细胞死亡，而另一个突变体则产生浑浊的噬菌斑，有时很难看到。透明斑变体对BHK-21细胞引起明显的细胞病变作用，但混浊的变体则不引起。由于明显的变异，它也干扰了细胞病变作用。发现通过脑的LCM病毒主要由透明菌斑型组成，而通过肝的LCM病毒主要是浊斑型。透明型在成年小鼠脑内接种后诱发惊厥和早期死亡;浑浊的变体没有引起抽搐和晚死。在新生小鼠中，透明斑块型致死性一致，而浑浊的变体没有引起死亡，而是引起持续的耐受性感染。

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