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首页> 外文期刊>Infection and immunity >Production of Staphylococcal Alpha Toxin I. Relationship Between Cell Growth and Toxin Formation
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Production of Staphylococcal Alpha Toxin I. Relationship Between Cell Growth and Toxin Formation

机译：金黄色葡萄球菌α毒素的产生I.细胞生长与毒素形成之间的关系

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Alpha toxin production and its relationship to cell growth were studied in the Wood 46 strain of Staphylococcus aureus. Toxin first appeared in the culture in the late logarithmic stage, but at least 80% was produced during the subsequent period of slower cell growth. The toxin concentration per unit of cell mass or viable count increased continually throughout the period of toxin production and and at its maximum represented 1.6 to 2.0% of the dry weight of the cells. The possibility that alpha toxin is released as a result of cell lysis was examined by using the appearance of cellular deoxyribonucleic acid in the medium as an indicator of lysis. The results showed that no appreciable amount of lysis occurred during toxin production; at a time when almost maximum amounts of toxin were present in the culture, less than% 4 of the cells had lysed. This finding, together with the observation that less than 0.25% of the total amount of toxin in the culture could be found intracellularly, indicates that alpha toxin is released from intact cells shortly after it is synthesized.
机译：研究了金黄色葡萄球菌Wood 46菌株中α毒素的产生及其与细胞生长的关系。毒素最早在对数后期出现在培养物中，但是在随后的细胞生长缓慢的过程中至少产生了80％。在毒素产生的整个过程中，每单位细胞质量或活菌计数的毒素浓度持续增加，并且其最大值代表细胞干重的1.6％至2.0％。通过使用培养基中细胞脱氧核糖核酸的出现作为裂解的指标，检查了由于细胞裂解而释放出α毒素的可能性。结果表明，在毒素产生过程中没有发生明显的裂解。当培养物中几乎存在最大量的毒素时，不到4％的细胞裂解了。这一发现，加上观察到在细胞内发现的培养物中毒素总量不到0.25％的观察结果表明，α毒素在合成后不久便从完整细胞中释放出来。

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