...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Acute Cavitary Histoplasmosis in Rhesus Monkeys: Influence of Immunological Status
【24h】

Acute Cavitary Histoplasmosis in Rhesus Monkeys: Influence of Immunological Status

机译：恒河猴急性空腹组织胞浆菌病：免疫状态的影响。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Male rhesus monkeys were randomized into groups according to body weight, immunized with different Histoplasma capsulatum antigens, and two weeks later were infected intratracheally with 108H. capsulatum yeast cells. Complement fixation antibody titers, skin tests, and chest X rays were performed at weekly intervals from immunization until autopsy, at which time the spleens were cultured and the lungs and other organs were dissected. Pulmonary cavities were found in 33% of the animals, and extrapulmonary dissemination was present in 85% of the animals. Delayed hypersensitivity and circulating antibody activity was detected in all animals at some time during the experimental period; however, animals which developed pulmonary cavities had a longer period before circulating antibodies were detected than animals which did not develop pulmonary cavities. Delayed hypersensitivity developed at approximately the same time in both cavitary and noncavitary animals. Early appearance of delayed hypersensitivity was associated with reduced amounts of extrapulmonary dissemination, in that animals with a later onset of skin test reactivity had more H. capsulatum cultured from the spleen. There was no correlation between the onset or titers of circulating antibodies and the spleen culture results.
机译：根据体重将雄性恒河猴随机分组，用不同的荚膜荚膜抗原免疫，两周后气管内用10 8 H感染。荚膜酵母细胞。从免疫到尸检，每隔一周进行补体固定抗体滴度，皮肤测试和胸部X射线检查，然后培养脾脏并解剖肺和其他器官。在33％的动物中发现了肺腔，在85％的动物中存在了肺外扩散。在实验期间的某些时间，在所有动物中检测到迟发型的超敏反应和循环抗体活性。然而，与没有形成肺腔的动物相比，形成肺腔的动物在检测到循环抗体之前的时间更长。空化和非空化动物在大约同一时间出现迟发性超敏反应。迟发型超敏反应的早期出现与减少的肺外扩散量有关，因为皮肤测试反应性较晚发作的动物具有更高的 H。脾脏培养的荚膜。循环抗体的发作或滴度与脾培养结果之间没有相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号