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Increased Toxicity of Double-Stranded Ribonucleic Acid in Virus-Infected Animals

机译：病毒感染动物中双链核糖核酸的毒性增加

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Virus-infected mice were significantly more susceptible to the toxic effects of double-stranded ribonucleic acid (RNA) than uninfected mice. A dramatic increase in mortality was observed after injection of either synthetic (polyriboinosinic·polyribocytidylic acid) or natural (mycophage) double-stranded RNA in mice infected with Newcastle disease virus (NDV) or vesicular stomatitis virus (VSV). With the exception of endotoxin, interferon inducers other than double-stranded RNA, such as tilorone-hydrochloride and chlorite-oxidized oxyamylose, did not show this increased toxicity in virus-infected animals. The increased susceptibility of virus-infected animals to the toxic effects of double-stranded RNA appears to be related to the levels of interferon induced by the virus infection, either systemically, in the blood stream (after inoculation of NDV), or locally, in the brain (after infection with VSV).
机译：与未感染的小鼠相比，感染了病毒的小鼠对双链核糖核酸（RNA）的毒性作用更为敏感。在注射了新城疫病毒（NDV）或水泡性口炎病毒（VSV）的小鼠中注射了合成的（聚核糖核酸·多核糖基酸）或天然的（支链噬菌体）双链RNA后，观察到死亡率显着增加。除内毒素外，除双链RNA外的干扰素诱导剂，如盐酸替洛龙和亚氯酸盐氧化的羟直链淀粉，在病毒感染的动物中均未显示出这种增加的毒性。被病毒感染的动物对双链RNA毒性作用的敏感性增加似乎与病毒感染诱导的干扰素水平有关，无论是全身性的，在血液中（接种NDV后）还是局部地在体内。大脑（感染VSV后）。

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