Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin

E. T. Rietschel; Y. B. Kim; D. W. Watson; C. Galanos; O. Lüderitz; O. Westphal

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Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin

机译：脂质A与牛血清白蛋白或人血清白蛋白复合的热原性和免疫原性

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The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A·BSA and lipid A·HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity.

机译：细菌脂多糖（内毒素）的脂质A成分与牛血清白蛋白（BSA）或人血清白蛋白（HSA）复合时，被证明是有效的热原。此外，通过用脂质A·BSA和脂质A·HSA复合物免疫，可以保护兔子免受内毒素热。本文提供的结果表明，脂质A负责内毒素的热原活性及其诱导热原性免疫的能力。

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《Infection and immunity》 |1973年第2期|共5页
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E. T. Rietschel; Y. B. Kim; D. W. Watson; C. Galanos; O. Lüderitz; O. Westphal;
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中图分类医学免疫学;
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1. The lipopolysaccharide-induced pro-inflammatory response in RAW264.7 cells is attenuated by an unsaturated fatty acid-bovine serum albumin complex and enhanced by a saturated fatty acid-bovine serum albumin complex [J] . ChangC.F., ChauY.P., KungH.N., Inflammation research: Official journal of the European Histamine Research Society . 2012,第2期

机译：脂多糖诱导的RAW264.7细胞的促炎反应被不饱和脂肪酸-牛血清白蛋白复合物减弱，并被饱和脂肪酸-牛血清白蛋白复合物增强
2. The lipopolysaccharide-induced pro-inflammatory response in RAW264.7 cells is attenuated by an unsaturated fatty acid–bovine serum albumin complex and enhanced by a saturated fatty acid–bovine serum albumin complex [J] . Chi Fen Chang, Yat Pang Chau, Hsiu Ni Kung, Inflammation Research . 2012,第2期

机译：脂多糖诱导的RAW264.7细胞促炎反应被不饱和脂肪酸-牛血清白蛋白复合物减弱，并被饱和脂肪酸-牛血清白蛋白复合物增强
3. Influence of myristic acid on furosemide binding to bovine serum albumin. Comparison with furosemide–human serum albumin complex [J] . B. Bojko, A. Sukowska, M. Maciaz ek-Jurczyk, Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2010,第1期

机译：肉豆蔻酸对呋塞米与牛血清白蛋白结合的影响。与速尿-人血清白蛋白复合物的比较
4. Comparison of human serum and bovine serum albumins on oxidation dynamics induced by talaporfin sodium photosensitization reaction with albumin rich conditions: solution experiments [C] . Mariko. Kurotsu, Tetsuya. Nakamura, Mei. Takahashi, Optical interactions with tissue and cells XXV; and Terahertz for Biomedical Applications . 2014

机译：富白蛋白条件下人血清和牛血清白蛋白对他拉泊芬钠光敏反应诱导的氧化动力学的比较：
5. Red Fluorescence in Bovine Serum Albumin - Gold Complexes [D] . Dixon, Jacob Michael 2019

机译：牛血清白蛋白中的红色荧光-金配合物
6. Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin [O] . E. T. Rietschel, Y. B. Kim, D. W. Watson, 1973

机译：脂质A与牛血清白蛋白或人血清白蛋白复合的热原性和免疫原性
7. The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities [O] . Mackenzie Peter Ian, Miners John Oliver, Knights Kathleen Mary, 2008

机译：“白蛋白作用”与药物葡萄糖醛酸化：牛血清白蛋白和无脂肪酸的人血清白蛋白增强 UDP-葡萄糖醛酸转移酶（UGT）1A9底物的葡萄糖醛酸化作用，但UGT1A1没有和UGT1A6活动

Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin

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