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T Cell Dependence of Macrophage Activation and Mobilization During Infection with Mycobacterium tuberculosis

机译：结核分枝杆菌感染过程中巨噬细胞活化和动员的T细胞依赖性

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Mice made T cell-deficient as adults by thymectomy and lethal irradiation, and infected with Mycobacterium tuberculosis, showed a greatly reduced capacity to develop nonspecific resistance to challenge with a heterologous bacterium. The capacity to develop nonspecific resistance was restored, however, by an infusion of syngeneic thymocytes. Evidence was presented which showed that the capacity of mycobacteria-infected mice to resist a lethal challenge with a heterologous organism rested on the capacity of macrophages existing at the time of challenge to reduce the number of challenge organisms to a sublethal level within 8 h. This antibacterial activity of macrophages was substantially reduced in T cell-deficient mice but could be restored by an infusion of syngeneic thymocytes. It was concluded that T cell-deficient mice have a reduced capacity to mobilize and activate macrophages because of their reduced capacity to respond immunologically to antigens of M. tuberculosis.
机译：通过胸腺切除术和致死性辐射使成年小鼠的T细胞缺乏，并感染了结核分枝杆菌，它们对异源细菌产生非特异性抗性的能力大大降低。然而，通过注入同基因胸腺细胞，恢复了产生非特异性抗性的能力。提出的证据表明，分枝杆菌感染的小鼠抵抗异源生物致死性攻击的能力取决于攻击时存在的巨噬细胞在8小时内将攻击性生物数量减少至亚致死水平的能力。在缺乏T细胞的小鼠中巨噬细胞的这种抗菌活性大大降低，但是可以通过注入同基因胸腺细胞来恢复。结论是缺乏T细胞的小鼠动员和激活巨噬细胞的能力降低，因为它们对 M的抗原产生免疫应答的能力降低。结核病。

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