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首页> 外文期刊>Infection and immunity >Serum immunoglobulin, dermal response, and lymphocyte transformation studies in horses with chronic diarrhea.
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Serum immunoglobulin, dermal response, and lymphocyte transformation studies in horses with chronic diarrhea.

机译：患有慢性腹泻的马的血清免疫球蛋白，皮肤反应和淋巴细胞转化研究。

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Serum specimens from 12 sick and 20 normal horses were examined for levels of different classes of immunoglobulin (Ig) by a single radial immunodiffusion. The level of IgA in the sera of sick horses was about 50% lower than in the sera of normal horses. By contrast, the level of serum IgG was higher in sick than in normal horses. Phytohemagglutinin (PHA) responsiveness of blood lymphocytes showed transient suppression during the stage of severe diarrhea. The regaining of PHA responsiveness of lymphocytes was observed simultaneously with the recovery process. However, the responsiveness of lymphocytes in recovered horses was still markedly lower than in normal horses. Allergic reactions in sick and normal horses were studied by observing dermal response to the injections of saline extracts from some of the horse feeds. A delayed hypersensitivity reaction to streptokinase-streptodornase and PHA was also studied. The allergic reactions to these extracts were not induced in either sick or normal horses; however, inflammatory response to the extracts was about 50% greater in normal than sick horses. Response to the intradermal injection, either streptokinase-streptodornase or PHA, was significantly greater in normal horses than sick horses. These findings are discussed with respect to the pathogenesis of chronic diarrhea and the complexity of immunodeficiency demonstrated in this disease. The possibility that transient defects of cell-mediated immunity may predispose to chronic diarrhea is proposed.
机译：通过一次径向免疫扩散检查了12匹病马和20匹正常马的血清标本中不同类别的免疫球蛋白（Ig）的水平。患病马血清中的IgA水平比正常马血清中的IgA水平低约50％。相反，患病的血清IgG水平高于正常马匹。在严重腹泻阶段，血液淋巴细胞的植物血凝素（PHA）反应性显示出短暂的抑制作用。在恢复过程中同时观察到淋巴细胞PHA反应性的恢复。然而，康复马匹中淋巴细胞的反应性仍然明显低于正常马匹。通过观察对注射某些马饲料中的盐水提取物的皮肤反应，研究了病马和正常马的过敏反应。还研究了对链激酶-链脲酶和PHA的迟发型超敏反应。对这些提取物的过敏反应在生病或正常的马中均未引起。然而，正常情况下，对提取物的炎症反应比病马高出约50％。在正常马匹中，对皮内注射的反应（链激酶-链霉烯酶或PHA）明显大于病马。讨论了这些发现，涉及慢性腹泻的发病机理以及该疾病中免疫缺陷的复杂性。有人提出了细胞介导的免疫系统暂时性缺陷可能导致慢性腹泻的可能性。

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