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首页> 外文期刊>Infection and immunity >Neuropathological effects of persistent infection of mice by mouse hepatitis virus.
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Neuropathological effects of persistent infection of mice by mouse hepatitis virus.

机译：小鼠肝炎病毒持续感染小鼠的神经病理学作用。

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Mouse hepatitis virus (MHV3) can persist for months in strains of mice with genetically controlled "semisusceptibility" to this virus. The pathology of the chronic neurological disease induced in these animals has been investigated by conventional histology and immunofluorescence. A2G mice develop a chronic choroidoependymitis and meningitis leading to severe hydrocephalus and hydromyelia. In C3H mice a widespread vasculitis was observed, with both viral antigens and bound immunoglobulins in vessal walls. No significant glomerulonephritis was found. Systemic amyloidosis was present in the spleen, liver, and kidneys. The virus was not detected in neural tissues, but brain and spinal cord lesions were found near inflammatory areas surrounding damaged vessels. It is suggested that viral persistance in ependymal cells is directly responsible for the lesions in A2G mice, whereas an immunopathological lesion of blood vessels of the central nervous system underlines the damage to mice of the C3H strain.
机译：小鼠肝炎病毒（MHV3）在对该病毒具有遗传控制的“半敏感性”的小鼠品系中可以持续数月。已经通过常规组织学和免疫荧光研究了在这些动物中诱发的慢性神经系统疾病的病理学。 A2G小鼠发展为慢性脉络膜表皮炎和脑膜炎，导致严重的脑积水和脊髓积水。在C3H小鼠中，观察到广泛的血管炎，囊壁中有病毒抗原和结合的免疫球蛋白。未发现明显的肾小球肾炎。全身淀粉样变性病存在于脾脏，肝脏和肾脏中。在神经组织中未检测到该病毒，但在受损血管周围的炎症区域附近发现了大脑和脊髓损伤。有人认为，室管膜细胞中的病毒持续性是造成A2G小鼠损伤的直接原因，而中枢神经系统血管的免疫病理损伤则突显了C3H株对小鼠的损伤。

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