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首页> 外文期刊>Infection and immunity >Inhibition of streptococcal attachment to receptors on human buccal epithelial cells by antigenically similar salivary glycoproteins.
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Inhibition of streptococcal attachment to receptors on human buccal epithelial cells by antigenically similar salivary glycoproteins.

机译：抗原相似的唾液糖蛋白抑制链球菌附着于人颊上皮细胞上的受体。

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Preparations of salivary glycoproteins inhibited the attachment of certain indigenous oral streptococci to human buccal epithelial cells and fostered the desorption of previously attached bacteria. The adherence-inhibiting and desorptive activities of the glycoproteins correlated with their ability to aggregate these organisms. Pretreatment of glycoprotein preparations with certain blood group antisera impaired their adherence-inhibiting effect, suggesting that components with blood group substance reactivity were involved. Pretreatment of buccal epithelial cells with certain blood group antisera or concanavalin A masked the receptors associated with the attachment of Streptococcus sanguis SG1. The association of blood-group-reactive substances with the receptors involved in bacterial attachment may provide a basis for understanding the distinct specificities that bacteria exhibit for attaching to different tissues, organs, and hosts. Antiserum raised in rabbits to human epithelial cells also exhibited receptor-masking activity, and absorption of this serum with homologous salivary glycoproteins removed the antibodies responsible. These observations indicate that some salivary glycoproteins are antigenically similar to components on the epithelial cell surfaces they bathe. It is suggested that by mimicking the receptors present on epithelial cells, the mucinous glycoproteins of secretions may competitively inhibit the sorption of infectious agents and facilitate their removal after they are attached. These activities help to explain how mucinous glycoproteins augment the cleansing action of secretions.
机译：唾液糖蛋白制剂可抑制某些本地口腔链球菌附着于人颊上皮细胞，并促进先前附着细菌的解吸。糖蛋白的粘附抑制和解吸活性与其聚集这些生物的能力有关。用某些血型抗血清对糖蛋白制剂进行预处理会削弱其粘附抑制作用，表明涉及具有血型物质反应性的成分。用某些血型抗血清或伴刀豆球蛋白A预处理颊上皮细胞可掩盖与血链球菌SG1附着相关的受体。血型反应性物质与参与细菌附着的受体的结合可以为理解细菌表现出的附着于不同组织，器官和宿主的不同特异性提供基础。在兔中对人上皮细胞产生的抗血清也表现出受体掩盖活性，并且该血清与同源唾液糖蛋白的吸收消除了负责的抗体。这些观察结果表明一些唾液糖蛋白在抗原上类似于它们所浸入的上皮细胞表面上的成分。建议通过模仿存在于上皮细胞上的受体，分泌物的粘液糖蛋白可以竞争性地抑制传染原的吸附，并在附着后促进它们的去除。这些活动有助于解释粘蛋白糖蛋白如何增强分泌物的清洁作用。

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