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Transfer of Adoptive Immunity to Tuberculosis in Mice

机译：过继性免疫转移至小鼠结核病

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A system is described for studying adoptive immunity to tuberculosis in syngeneic mice. Donor mice were immunized with 104 BCG intravenously, and lymphoid cells were harvested 28 days later. Adoptive immunity was measured in recipient mice in terms of the inhibition of growth of BCG in the liver and spleen following intravenous injection. Adoptive immunity was expressed optimally when recipients were sublethally irradiated (500 R), challenged with 104 to 105 viable organisms, and given sensitized lymphoid cells intravenously. Adoptive immunity was not manifest until 14 days after challenge and was effective against Mycobacterium tuberculosis H37Rv as well as BCG. Immunity could be conferred by spleen, lymph node, peritoneal exudate, and resident peritoneal (washout) cells. The lymphoid cells conferring immunity were shown to be thymus-dependent lymphocytes by virtue of their nonadherence to glass wool and sensitivity to anti-θ serum plus complement. The sensitized cells were relatively susceptible to both in vitro and in vivo X-irradiation.
机译：描述了一种用于研究同基因小鼠对结核的过继免疫的系统。用10 4 BCG静脉免疫供体小鼠，28天后收集淋巴细胞。通过抑制静脉注射后BCG在肝脏和脾脏中的生长，在受体小鼠中测量了过继免疫。当接受亚致死剂量（500 R），接受10 4 到10 5 活菌攻击并静脉内给予致敏的淋巴样细胞时，最佳的过表达免疫力。攻击后14天才出现过继免疫，并且对结核分枝杆菌H37Rv和卡介苗均有效。脾脏，淋巴结，腹膜渗出液和常驻腹膜（冲洗）细胞可赋予免疫力。赋予免疫力的淋巴样细胞由于不粘附玻璃棉和对抗θ血清加补体的敏感性而显示为胸腺依赖性淋巴细胞。致敏细胞对体外和体内X射线照射均相对敏感。

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