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首页> 外文期刊>Infection and immunity >Increased antibacterial activity against Escherichia coli in bovine serum after the induction of endotoxin tolerance.
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Increased antibacterial activity against Escherichia coli in bovine serum after the induction of endotoxin tolerance.

机译：诱导内毒素耐受后，牛血清中对大肠杆菌的抗菌活性增加。

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Small amounts of endotoxin injected intramuscularly into cows induced endotoxin pyrogenic tolerance and an increase in the rate at which the serum killed a strain of Escherichia coli. Most of the difference between normal serum and serum from the endotoxin-tolerant animal was shown to be due to a bentonite-adsorbable factor other than lysozyme or beta-lysin. The antibacterial activity was not completely removed from either type of serum after bentonite adsorption. Electron microscope studies and measurement of the rate of release of radioactively labeled cytoplasmic contents showed that the bentonite-adsorbable factor was important in the final breakdown of the cell membrane and release of cellular contents. The antibacterial system was totally dependent on complement, and the importance of antibodies could not be entirely ruled out because adsorption at O C with homologous cells eliminated the killing activity.
机译：肌内注射到奶牛中的少量内毒素会引起内毒素热原性耐受性的提高，并导致血清杀死大肠杆菌的速度增加。正常血清与耐内毒素动物的血清之间的大部分差异显示是由于溶菌酶或β-溶血素以外的膨润土可吸附因子引起的。膨润土吸附后，没有从两种血清中完全去除抗菌活性。电子显微镜研究和放射性标记的胞质内含物释放速率的测量表明，膨润土吸附因子在细胞膜的最终分解和细胞内含物的释放中很重要。抗菌系统完全依赖补体，不能完全排除抗体的重要性，因为同源细胞在O C上的吸附消除了杀伤活性。

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