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首页> 外文期刊>Infection and immunity >Immunoprophylaxis of experimental Mycoplasma pneumoniae disease: effect of aerosol particle size and site of deposition of M. pneumoniae on the pattern of respiratory infection, disease, and immunity in hamsters.
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Immunoprophylaxis of experimental Mycoplasma pneumoniae disease: effect of aerosol particle size and site of deposition of M. pneumoniae on the pattern of respiratory infection, disease, and immunity in hamsters.

机译：实验性肺炎支原体疾病的免疫预防：气溶胶颗粒大小和肺炎支原体的沉积部位对仓鼠呼吸道感染，疾病和免疫的模式的影响。

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摘要

The distribution of Mycoplasma pneumoniae infection in the respiratory tract and the extent of pulmonary pathology were determined by the site of deposition and the number of organisms administered to hamsters. Infection of the upper and lower areas of the respiratory tract occurred when organisms were introduced into both areas by small-particle aerosol (2.3 micrometer) or by intranasal (i.n.) instillation of a 200-microliter inoculum. In contrast, when organisms were delivered primarily to the upper respiratory tract by large-particle aerosol (8 micrometer) or by i.n. instillation of a small volume of inoculum (2 or 20 microliter), infection remained limited to this area in most or all instances. When the lungs became infected after i.n. administration of a 200-microliter inoculum, the most extensive pulmonary lesions were seen in the animals given the largest number of organisms. Each of the modes of administration of M. pneumoniae initiated an infection which conferred measurable resistance to a subsequent challenge capable of inducing extensive pulmonary disease. The most effective resistance was induced by the two modes of administration which produced an infection involving the entire respiratory tract, i.e., small-particle aerosol or i.n. instillation of a 200-microliter inoculum.
机译：肺炎支原体感染在呼吸道中的分布和肺部病变的程度由沉积位点和仓鼠施用的生物数量决定。当通过小颗粒气雾剂（2.3微米）或鼻内（i.n.）滴注200微升接种物将有机体引入两个区域时，会感染呼吸道的上部和下部区域。相反，当有机物主要通过大颗粒气雾剂（8微米）或经i.n.传递到上呼吸道时。滴入少量接种物（2或20微升）后，在大多数情况下或全部情况下，感染仍局限于该区域。当i.n.之后肺部受到感染时给予200微升接种物后，在给动物最多生物的情况下，发现最广泛的肺部病变。肺炎支原体的每种给药方式均引起感染，该感染赋予对可诱发广泛肺部疾病的随后挑战的可测量的抗性。最有效的抗药性是由两种给药方式诱导的，产生了涉及整个呼吸道的感染，即小颗粒气雾剂或感染。滴入200微升接种物。

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