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首页> 外文期刊>Infection and immunity >Inhibition of small-intestinal sugar and amino acid transport by the enterotoxin of Shigella dysenteriae I.
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Inhibition of small-intestinal sugar and amino acid transport by the enterotoxin of Shigella dysenteriae I.

机译:痢疾志贺氏菌I肠毒素对小肠糖和氨基酸转运的抑制作用。

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The enterotoxin of Shigella dysenteriae I produces fluid and electrolyte secretion in the rabbit ileum. These present studies were designed to evaluate nonelectrolyte transport in rabbit ileal mucosa exposed to Shigella enterotoxin. Both 10 mM galactose and 5 mM L-alanine absorptions were significantly impaired in enterotoxin-exposed ileal mucosa compared with control mucosa. L-Alanine influx was not imparied in two other secretory processes: that induced by cholera enterotoxin and hyperosmolarity. These studies provide evidence that both surgar and amino acid absorptions are diminished in the small intestine by the enterotoxin of S. dysenteriae I.
机译:痢疾志贺氏菌I的肠毒素在兔回肠中产生液体和电解质分泌。这些本研究旨在评估暴露于志贺氏菌肠毒素的兔回肠粘膜中的非电解质转运。与对照粘膜相比,肠毒素暴露的回肠粘膜中10 mM半乳糖和5 mM L-丙氨酸吸收均显着受损。 L-丙氨酸流入不受其他两个分泌过程的影响:由霍乱肠毒素和高渗性引起。这些研究提供证据,表明痢疾链球菌I的肠毒素降低了小肠中的糖和氨基酸的吸收。

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