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首页> 外文期刊>Infection and immunity >In vivo interference in vesicular stomatitis virus infection.
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In vivo interference in vesicular stomatitis virus infection.

机译：体内干扰水疱性口炎病毒感染。

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Inactivated defective interfering and complete particles of vesicular stomatitis virus given intracerebrally to adult mice protect them against challenge with homologous virus whether this is given at the same time or several days later. Two separate protective processes appear to be involved. The first, which comes into operation immediately after inoculation, is also effective against heterologous strains of vesicular stomatitis virus, rabies (another rhabdovirus), and a neurotropic strain of foot-and-mouth disease virus. The second, later effect, which is strain specific, appears to be correlated with the appearance of circulating neutralizing antibody. Our results suggest that the protective effect that Holland and his colleagues described using defective interfering particles of vesicular stomatitis virus may also be accounted for by an immunological mechanism rather than one involving interference.
机译：脑内给予成年小鼠的灭活的有缺陷的干扰性和完整的水泡性口炎病毒颗粒，无论是在同一时间还是在几天后，都可以保护它们免受同源病毒的攻击。似乎涉及两个单独的保护过程。第一种疫苗在接种后立即生效，也可有效抵抗异源性水疱性口炎病毒，狂犬病（另一种弹状病毒）和神经营养性口蹄疫病毒。第二个稍后的效应是菌株特异性的，似乎与循环中和抗体的出现有关。我们的研究结果表明，Holland和他的同事描述的使用水疱性口炎病毒的缺陷干扰颗粒的保护作用也可能是由免疫机制而非涉及干扰的机制引起的。

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