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Evaluation of the Immune Response Directed Against the Salmonella Antigenic Factors O4,5 and O9

机译：针对沙门氏菌抗原因子O4、5和O9的免疫应答的评估

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A pair of O4,5,12 and O9,12 his+ sister transductants derived from a virulent Salmonella typhimurium parent were used as intraperitoneal and oral challenge strains to determine whether immunity directed against the O9 and O4,5 antigenic components could be detected after immunization with heat-killed vaccines containing one or the other of these antigenic components. Challenge with a mixture (ca. 1:1) of the two strains and culturing of livers and spleens at intervals indicated that the O4,5,12 strain multiplied to a greater extent than the O9,12 strain after both oral and intraperitoneal challenge of CF1 and C57BL/6J control mice. Immunization with O4,5,12 or O9,12 vaccine resulted in diminished bacterial counts from the livers and spleens for the homologous strain but had little effect on the heterologous strain. The diminution of the homologous strain was more evident after intraperitoneal challenge but was clearly demonstrable after oral challenge, particularly in the C57BL/6J mice. Of several live vaccines tested, an FOR S. typhimurium (O4,5,12) strain phenotypically smooth but avirulent seemed the most promising, suppressing the multiplication of both members of the challenge pair. After oral challenge suppression of the O4,5,12 strain was greater. These results indicate that the specific immune response directed against either the O4,5 (O-acetyl abequose) or the O9 (tyvelose) antigen is a measurable component of the overall response after both intraperitoneal and oral challenge.
机译：一对强毒的鼠伤寒沙门氏菌亲本衍生的O4,5,12和O9,12的 his + 姐妹转导体被用作腹膜内和口服攻击菌株以确定是否可以用含有一种或另一种抗原成分的热灭活疫苗免疫后检测到针对O9和O4,5抗原成分的免疫力。用两种菌株的混合物（约1：1）进行攻击，并间隔培养肝脏和脾脏，这表明口服和腹膜内攻击O4,5,12菌株比O9,12菌株增殖程度更大。 CF1和C57BL / 6J对照小鼠。用O4,5,12或O9,12疫苗免疫后，同源菌株的肝脏和脾脏细菌数量减少，但对异源菌株的影响很小。腹膜内攻击后，同源菌株的减少更为明显，但口服攻击后，尤其是在C57BL / 6J小鼠中，这明显可证明。在测试的几种活疫苗中，FOR S。鼠伤寒沙门氏菌（O4,5,12）表型光滑，但无毒似乎最有希望，抑制了攻击对的两个成员的繁殖。口服攻击后，对O4,5,12菌株的抑制作用更大。这些结果表明，针对O4,5（O-乙酰基b基）或O9（酪蛋白）抗原的特异性免疫反应是腹膜内和口服激发后总体反应的可测量成分。

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