Multistability in a prion replication interconnected cell reaction network <ce:cross-ref refid='fn1'> <ce:sup loc='post'>?</ce:sup> </ce:cross-ref>

J.M. Méndez-González; Irene Otero-Muras

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Multistability in a prion replication interconnected cell reaction network ?

机译：ion病毒复制互连细胞反应网络中的多重稳定性？

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Aggregation of misfolded proteins has been implicated in a number of neurodegenerative disorders including prion disease. In spite of intensive research, the detailed mechanisms of protein misfolding leading to protein aggregation remain unsolved. Here, we explore the capacity for bistability of several classes of mechanisms proposed in the literature and compatible with protein aggregation kinetic data sets (it has been shown that bistability explains thresholds phenomena observed in protein aggregationin vitroandin vivo).Using a novel method for bistability detection we find a plausible scenario for which the so called subsequent monomer addition model leads to bistability.

机译：错误折叠的蛋白质的聚集与包括病毒疾病在内的许多神经退行性疾病有关。尽管进行了深入研究，但导致蛋白质聚集的蛋白质错误折叠的详细机制仍未解决。在这里，我们探讨了文献中提出的几种与蛋白质聚集动力学数据集兼容的机制的双稳态能力（已证明双稳态解释了在体内和体外蛋白质聚集中观察到的阈值现象）。使用一种新的双稳态检测方法我们发现了一个合理的场景，所谓的后续单体添加模型会导致双稳态。

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来源
《IFAC PapersOnLine》 |2018年第19期|共2页
作者
J.M. Méndez-González; Irene Otero-Muras;
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中图分类自动化技术、计算机技术;
关键词
BistabilityPrion kineticsInterconnected cellsBiochemical Reaction Network;

机译：双稳态Prion动力学互连的细胞生化反应网络;

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Multistability in a prion replication interconnected cell reaction network ?

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