Antigens of Mycobacterial Cell Walls

K. H. Wong; M. J. Pickett; S. Froman

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Antigens of Mycobacterial Cell Walls

机译：分枝杆菌细胞壁的抗原

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Three antigenic fractions from the cell walls of eight strains of mycobacteria were studied. Isolation and purification of these antigens were effected by enzymatic digestions, differential and sucrose gradient centrifugations, dialyses, and column chromatography. Two of the fractions were termed cell wall tuberculins (CWT-1, solubilized with lipase; CWT-2, solubilized with lysozyme); the third was termed “C” (cross-reacting) antigen. All appeared to be lipopolysaccharides. The CWT antigens, as compared with purified protein derivatives (human), were relatively species (group)-specific in both double immunodiffusion and guinea pig skin tests; in the latter, the reactions resembled those of delayed hypersensitivity. The C antigens reacted heterologously in double immunodiffusion and skin tests; the latter were the “immediate” type of reaction.

机译：研究了来自八个分枝杆菌菌株的细胞壁的三个抗原级分。这些抗原的分离和纯化是通过酶消化，差异和蔗糖梯度离心，透析和柱色谱进行的。其中两个级分称为细胞壁结核菌素（CWT-1，被脂肪酶溶解; CWT-2，被溶菌酶溶解）;第三个被称为“ C”（交叉反应）抗原。似乎都是脂多糖。与纯化的蛋白质衍生物（人类）相比，CWT抗原在双重免疫扩散和豚鼠皮肤试验中具有相对物种（组）特异性;在后者中，反应类似于迟发型超敏反应。 C抗原在双重免疫扩散和皮肤试验中异源反应;后者是“立即”类型的反应。

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《Infection and immunity》 |1970年第4期|共8页
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K. H. Wong; M. J. Pickett; S. Froman;
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中图分类医学免疫学;
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1. Heterogeneity of monoclonal antibody-reactive epitopes on mycobacterial 30-kilodalton-region proteins and the secreted antigen 85 complex and demonstration of antigen 85B on the Mycobacterium leprae cell wall surface. [J] . A Rambukkana, P K Das, J D Burggraaf, Infection and immunity . 1992,第12期

机译：分支杆菌30-千达尔顿区蛋白和分泌的抗原85复合物上的单克隆抗体反应性表位的异质性，以及麻风分枝杆菌细胞壁表面上抗原85B的表现。
2. Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall. [J] . Gobec S, Plantan I, Mravljak J, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2007,第1期

机译：抗原85C的膦酸酯抑制剂的设计，合成，生化评估和抗分枝杆菌作用，85C是参与分枝杆菌细胞壁生物合成的关键酶。
3. Identification and characterization of epitopes shared between the mycobacterial 65-kilodalton heat shock protein and the actively secreted antigen 85 complex: their in situ expression on the cell wall surface of Mycobacterium leprae. [J] . A Rambukkana, P K Das, J D Burggraaf, Infection and immunity . 1992,第11期

机译：鉴定和表征分枝杆菌65-千洛酮热休克蛋白和主动分泌的抗原85复合物之间共享的表位：它们在麻风分枝杆菌的细胞壁表面上原位表达。
4. Synthesis of arabinan fragments from mycobacterial call wall component towards the functional analysis of mycobacterial arabinan degrading enzymes [C] . Akihiro Ishiwata, Yukishige Ito 日本化学会春季年会講演予稿集 . 2018

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5. M. smegmatis IKEPLUS Immunization Reveals the Mycobacterial Ribosome as a Source of Novel CD4+ T cell Antigens [D] . Kennedy, Steven C. 2018

机译：耻垢分枝杆菌IKEPLUS免疫揭示了分枝杆菌核糖体是新型CD4 + T细胞抗原的来源
6. Heterogeneity of monoclonal antibody-reactive epitopes on mycobacterial 30-kilodalton-region proteins and the secreted antigen 85 complex and demonstration of antigen 85B on the Mycobacterium leprae cell wall surface. [O] . A Rambukkana, P K Das, J D Burggraaf, 1992

机译：分枝杆菌30-千达尔顿区蛋白和分泌的抗原85复合物上的单克隆抗体反应性表位的异质性麻风分枝杆菌细胞壁表面上的抗原85B证明。
7. Antigens of Mycobacterial Cell Walls [O] . K. H. Wong, M. J. Pickett, S. Froman 1970

机译：分枝杆菌细胞壁的抗原

Antigens of Mycobacterial Cell Walls

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