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Experimentally Induced Alterations in Antigenic Properties of an Arbovirus Serotype

机译：虫媒血清型抗原性的实验诱导改变。

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Antigenic properties of Getah virus were monitored during 80 serial passages in Vero tissue cultures. The parent virus lost its serotype identity by passage 80. A clone derived from the parent remained antigenically stable during passage. The experimentally induced antigenic alterations in Getah virus were attributable to the tissue culture host selection of constituent subpopulations of virus with properties unlike those of the original parent. The marked differences in neutralization titers of low- and high-passage virus were considered related to or influenced by (i) the variation in subpopulation selection of the virus during passage and (ii) the variation in availability of antigenic stimulants during preparation of antiserum.
机译：在Vero组织培养物中连续80次传代期间监测了Getah病毒的抗原特性。到80代，亲本病毒失去了血清型同一性。派生自亲本的克隆在传代过程中保持抗原稳定。实验证明，Getah病毒的抗原性改变可归因于组织培养宿主对病毒组成亚群的选择，这些亚群的特性与原始亲本不同。低和高传代病毒的中和效价的显着差异被认为与以下因素有关或受其影响：（i）传代过程中病毒亚群选择的变化;以及（ii）抗血清制备过程中抗原性刺激物可用性的变化。

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