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Effect of Various Viruses on the Responsiveness of Mouse Lymphocytes to Phytohemagglutinin Stimulation

机译：多种病毒对小鼠淋巴细胞对植物血凝素刺激反应的影响

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A comparison of viral-induced unresponsiveness of phytohemagglutinin (PHA)-induced deoxyribonucleic acid (DNA) synthesis of mouse lymphocytes was made by culturing the cells under identical conditions in the presence of HEPES buffer in a humid-air atmosphere. The degree of PHA-induced DNA synthesis was found to vary, depending upon the type of ribonucleic acid or DNA virus treatment. Myxovirus, paramyxoviruses, Mengo virus, leukemic viruses, herpesvirus, and vaccinia virus caused a depression in responsiveness, whereas lactic dehydrogenase virus, adenovirus, and polyoma virus induced an increase in DNA synthesis. Inhibition of DNA synthesis was significant only if the virus was added at 0 h or within the first 12 h after PHA stimulation. Time studies indicated that leukemic and nonleukemic viruses caused similar patterns in the alteration of PHA-induced DNA synthesis.
机译：通过在潮湿空气中在HEPES缓冲液存在下在相同条件下培养细胞，比较病毒诱导的植物血凝素（PHA）诱导的脱氧核糖核酸（DNA）合成的无反应性。发现PHA诱导的DNA合成的程度根据核糖核酸或DNA病毒处理的类型而变化。粘液病毒，副粘液病毒，Mengo病毒，白血病病毒，疱疹病毒和牛痘病毒引起反应性下降，而乳酸脱氢酶病毒，腺病毒和多瘤病毒引起DNA合成增加。仅当在PHA刺激后0小时或最初12小时内添加病毒时，DNA合成的抑制作用才显着。时间研究表明，白血病病毒和非白血病病毒在PHA诱导的DNA合成改变中引起相似的模式。

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