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首页> 外文期刊>Infection and immunity >Local Antibody Production in Experimental Pyelonephritis: Amount, Avidity, and Immunoglobulin Class
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Local Antibody Production in Experimental Pyelonephritis: Amount, Avidity, and Immunoglobulin Class

机译：实验性肾盂肾炎的局部抗体生产：数量，亲和力和免疫球蛋白类别

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Local antibody formation in infected rabbit kidneys was studied with three techniques: the ammonium sulfate precipitation technique, the enzyme-linked immunosorbent assay, and by binding of newly synthesized 14C-labeled antibodies to heat-killed bacteria. Local antibody was detected by day 11 of infection with all three techniques, and a significant correlation was found in titers by all three methods. In these studies, antibody synthesized early was in IgG and IgA class, whereas IgM antibodies appeared later (day 20) in the antibody response. No maturation of avidity of local antibody was noted with time. Since it was necessary to use different animals at each test occasion, individual differences in avidity could account for failure to note an increase in avidity with time.
机译：用三种技术研究了感染兔肾脏中的局部抗体形成：硫酸铵沉淀技术，酶联免疫吸附测定，以及新合成的 14 C标记抗体与热灭活细菌的结合。三种抗体在感染的第11天都检测到了局部抗体，并且通过三种方法在滴度中均发现了显着的相关性。在这些研究中，早期合成的抗体属于IgG和IgA类，而IgM抗体的抗体应答出现较晚（第20天）。随着时间的推移，未观察到局部抗体的亲和力成熟。由于必须在每个测试场合使用不同的动物，因此亲和力的个体差异可能导致无法注意到亲和力随时间增加。

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