• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Nature of the effector cells responsible for antibody-dependent cell-mediated killing of Cryptococcus neoformans.
【24h】

Nature of the effector cells responsible for antibody-dependent cell-mediated killing of Cryptococcus neoformans.

机译：负责抗体依赖性细胞介导的新型隐球菌杀死的效应细胞的性质。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Studies were performed to identify the types of human peripheral blood leukocytes capable of killing Cryptococcus neoformans in the presence of anticryptococcal antibody in vitro. A total of 24.1 +/- 2.7% (mean +/- standard error of the mean of four experiments) of the original cryptococcal inoculum survived in a mixed mononuclear, cell preparation (approximately 30% monocytes) after 4 h of incubation at 37 degrees C with rabbit anticryptococcal antibody. When phagocytic cells were removed, there was 36.4 +/- 4.6% survival in six experiments, compared with 52.8% survival in the presence of purified granulocytes (mean of two experiments) and 96.9 +/- 1% survival in the presence of purified T cells. There was never any significant killing in control mixtures that contained leukocytes with normal rabbit serum nor in those that contained anticryptococcal antibody without effector leukocytes. Significant antibody-dependent fungicidal activity was seen with ratios of effector to target cells as low as 6.25:1. These observations indicate that multiple types of peripheral blood leukocytes, excluding T cells, are capable of antibody-dependent fungicidal activity.
机译：进行了研究以鉴定在体外存在抗隐球菌抗体的情况下能够杀死新型隐球菌的人外周血白细胞的类型。在37度下孵育4小时后，原始的隐球菌接种物总共有24.1 +/- 2.7％（四个实验平均值的+/-标准误差）在混合的单核细胞制备物中（约30％单核细胞）存活。 C用兔抗隐球菌抗体。去除吞噬细胞后，六个实验中的存活率为36.4 +/- 4.6％，相比之下，存在纯化的粒细胞的存活率为52.8％（两个实验的平均值），存在纯化的T细胞的存活率为96.9 +/- 1％细胞。含有正常兔血清的白细胞的对照混合物和不含效应白细胞的抗隐球菌抗体的对照混合物都没有任何明显的杀伤力。效应子与靶细胞的比例低至6.25：1，可见明显的抗体依赖性杀真菌活性。这些观察结果表明，除了T细胞外，多种类型的外周血白细胞都具有抗体依赖性杀真菌活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号