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首页> 外文期刊>Infection and immunity >Complications and immunological studies of measles virus infection in antithymocyte-treated hamsters.
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Complications and immunological studies of measles virus infection in antithymocyte-treated hamsters.

机译：抗胸腺细胞治疗的仓鼠中麻疹病毒感染的并发症和免疫学研究。

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A study was done to investigate possible late central nervous system (CNS) complications of latent measles infection in hamsters. Signs of CNS disease, consisting of myoclonus and paralysis, occurred in some weanling hamsters inoculated intraperitoneally at 3 or 9 days of age with antithymocyte serum (ATS) and measles virus, but no late complications in adult life attributable to measles virus were seen. A single series of ATS injections plus an injection of measles virus resulted in sustained antibody formation postulated due to establishment of a latent viral infection, whereas similar treatment with normal rabbit serum plus virus caused no or minimal antibody response. The majority of hamsters receiving ATS as newborns and ATS plus virus as weanlings also did not produce antibody. This differential effect of ATS may be due to combined elimination of suppressor and helper cells in the latter ATS-treated group and of suppressor cells only in the former ATS-treated group. Cellular immunity could not be evaluated since lymphocytes from inoculated and uninoculated hamsters released equal and variable amounts of 51Cr for both infected and noninfected labeled, allogeneic hamster target cells.
机译：进行了一项研究，以调查仓鼠潜在麻疹感染的可能的晚期中枢神经系统（CNS）并发症。中枢神经系统疾病的症状包括肌阵挛和瘫痪，出现在3或9天龄腹膜内接种抗胸腺细胞血清（ATS）和麻疹病毒的一些断奶的仓鼠中，但未见到因麻疹病毒引起的成年后期并发症。一系列的ATS注射加上麻疹病毒注射会导致持续的抗体形成，推测是由于潜在的病毒感染的建立，而正常兔血清加病毒的类似治疗则没有或只有很少的抗体反应。仓鼠大多数接受新生作为ATS，而由于断奶而接受ATS加病毒的仓鼠也不产生抗体。 ATS的这种差异作用可能是由于在后一个ATS治疗组中抑制细胞和辅助细胞的联合消除以及仅在前一个ATS治疗组中抑制细胞的联合消除。由于已感染和未感染的仓鼠的淋巴细胞对感染和未感染的标记的同种异体仓鼠靶细胞均释放出相等且可变数量的51Cr，因此无法评估细胞免疫性。

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