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首页> 外文期刊>Infection and immunity >Intestinal fluid accumulation induced by oral challenge with Vibrio cholerae or cholera toxin in infant mice.
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Intestinal fluid accumulation induced by oral challenge with Vibrio cholerae or cholera toxin in infant mice.

机译：口服霍乱弧菌或霍乱毒素在婴儿小鼠中引起的肠液积聚。

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The diarrheal response of orally inoculated infant mice to viable Vibrio cholerae and purified cholera toxin was quantitated by means of a fluid accumulation (FA) ratio. The FA ratio is defined as the gut weight/remaining body weight. FA ratios were determined in relation to time of exposure and dose. Onset of fluid accumulation with viable cells of strains CA401 and 569B occurred 8 h postinoculation and reached a near maximum of 16 h. A dose of 4 x 10(6) colony-forming units of strain CA401 was required for a positive response 16 to 18 h postinoculation. Several other classical cholera strains demonstrated a similar dose-related response. Strain 569B, however, required a 100-fold higher dose to give a positive response. Several mutant cholera strains were decreased virulence in other model systems elicited FA ratios decreased from wild-type values. Onset of fluid accumulation which cholera toxin occurred 6 to 8 h postinoculation and reached a maximum by 10 h. A dose of 0.5 microng was required for a positive response 10 to 12 h postinoculation. The positive response to toxin could be inhibited by preincubation with specific antitoxin.
机译：口服接种的小鼠小鼠对霍乱弧菌和纯化的霍乱毒素的腹泻反应通过液体积聚（FA）比进行定量。 FA比定义为肠重量/剩余体重。确定FA比率与暴露时间和剂量有关。接种后8 h，菌株CA401和569B的活细胞开始积聚液体，并达到了近16h的最大值。接种后16到18 h阳性反应需要剂量为4 x 10（6）的CA401菌落形成单位。其他几种经典霍乱菌株也表现出相似的剂量相关反应。然而，菌株569B需要100倍高的剂量才能产生阳性反应。在其他模型系统中，几种突变型霍乱菌株的毒力降低，导致FA比率从野生型值降低。霍乱毒素在接种后6至8 h出现积液，并在10 h达到最大值。接种后10到12 h阳性反应需要0.5 microng的剂量。通过与特异性抗毒素预孵育可以抑制对毒素的阳性反应。

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