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Enhanced Resistance Against Junin Virus Infection Induced by Corynebacterium parvum

机译：小棒状杆菌诱导的抗胡宁病毒感染的增强抵抗力

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The effects of intraperitoneal administration of Corynebacterium parvum on the course of Junin virus infection in mice were investigated. This treatment produced enhanced resistance to the virus infection, evidenced by an increase in both survival times and the proportion of survivors. The protective effect was dependent upon the dose of C. parvum, and 280 μg/g of body weight was found to be the optimal dose. In various experiments, about 80% of the infected animals receiving this dose survived, whereas survival ranged between 0 and 20% among untreated infected mice. Maximal protection was afforded by C. parvum when administered simultaneously with the virus. A smaller but significant degree of resistance was induced by C. parvum given 3 or 6 days after infection. C. parvum injected before infection was ineffective. Viral titers measured in the brains of C. parvum-treated and untreated mice at various times after infection were found to be comparable. In addition, there were no significant differences between circulating-antibody titers measured either by neutralization tests or by complement fixation. Depression of the reticuloendothelial system by treatment with silica particles also resulted in enhanced resistance to Junin virus infection, suggesting that the protective effect of C. parvum is not likely to be due merely to its capacity to stimulate macrophages. The present data, highlighting that the presence of high titers of Junin virus and disease do not necessarily correlated, suggest that in mice this disease is not the consequence of cell damage caused directly by the virus but of a still undefined indirect mechanism induced by the virus, not necessarily mediated by macrophages.
机译：研究了小肠棒杆菌的腹膜内给药对小鼠朱宁病毒感染过程的影响。这种治疗增强了对病毒感染的抵抗力，这可以通过增加生存时间和幸存者比例来证明。保护作用取决于 C的剂量。小剂量，最佳剂量是280μg/ g体重。在各种实验中，接受该剂量的约80％受感染的动物存活，而未治疗的受感染小鼠的存活率介于0％至20％之间。 C提供了最大的保护。与病毒同时给药时会引起感染。 C诱导了较小但明显的抗性。感染后3或6天给予小鸡。 C。感染前注射小v无效。在 C的大脑中测得的病毒滴度。发现在感染后的不同时间，经parvum处理的小鼠和未经处理的小鼠具有可比性。另外，通过中和试验或补体固定测定的循环抗体滴度之间没有显着差异。用二氧化硅颗粒处理可降低网状内皮系统的抵抗力，从而增强了对Junin病毒感染的抵抗力，表明 C的保护作用。 parvum 不可能仅由于其刺激巨噬细胞的能力而引起。目前的数据突显了高滴度的Junin病毒的存在与疾病不一定相关，表明在小鼠中，这种疾病不是病毒直接引起的细胞损伤的结果，而是病毒尚未诱导的间接机制，不一定由巨噬细胞介导。

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