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首页> 外文期刊>Infection and immunity >Metabolic and Functional Characteristics of Alveolar Macrophages Recovered from Rats Exposed to Marijuana Smoke
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Metabolic and Functional Characteristics of Alveolar Macrophages Recovered from Rats Exposed to Marijuana Smoke

机译：从暴露于大麻烟雾的大鼠中发现的肺泡巨噬细胞的代谢和功能特征

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Pulmonary alveolar macrophages were obtained by bronchopulmonary lavage from male rats after 30 consecutive days of in vivo exposure to marijuana and tobacco smoke. No significant differences were found between either group of experimental animals and controls in the number of cells recovered, the protein content per 106 cells, or the percentage of cells that adhered to plastic surfaces. The ability of macrophages to phagocytize viable bacteria was not affected by exposure to either marijuana or tobacco smoke in that both treatment groups ingested Staphylococcus aureus over a 60-min period as well as did control cells. Differences were found between the groups, however, with respect to cellular metabolism. Marijuana smoke inhalation caused a small decrease in the amount of oxygen consumed by macrophages during phagocytosis, as compared with control cells. This may have been reflected in the even greater decrease in superoxide formation observed during particle engulfment by these treated cells. Tobacco smoke, on the other hand, increased oxygen consumption and was without effect on superoxide release. Neither tobacco nor marijuana smoke treatment had an effect on the direct oxidation of glucose via the hexose monophosphate shunt. Our results indicate that, despite several metabolic alterations in response to marijuana and tobacco smoke, alveolar macrophages were not compromised with respect to their ability to ingest a particulate challenge.
机译：在体内连续30天暴露于大麻和烟草烟雾后，通过支气管肺灌洗从雄性大鼠中获得肺泡巨噬细胞。在两组实验动物和对照组之间，在回收的细胞数量，每10 6 细胞的蛋白质含量或粘附在塑料表面的细胞的百分比之间均没有发现显着差异。巨噬细胞吞噬活菌的能力不受大麻或烟草烟雾的影响，因为两个治疗组均摄取了60分钟的金黄色葡萄球菌以及对照细胞。但是，两组之间在细胞代谢方面存在差异。与对照细胞相比，吸入大麻烟雾使巨噬细胞在吞噬过程中消耗的氧气量略有减少。这些处理过的细胞在颗粒吞噬过程中观察到的超氧化物形成的更大减少可能已经反映了这一点。另一方面，烟草烟雾增加了氧气消耗，并且对超氧化物的释放没有影响。烟草和大麻烟雾处理都不会通过己糖单磷酸盐旁路对葡萄糖的直接氧化产生影响。我们的结果表明，尽管对大麻和烟草烟雾有一些新陈代谢的改变，但肺泡巨噬细胞在摄取颗粒挑战的能力方面并未受到损害。

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