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首页> 外文期刊>Infection and immunity >Group B streptococcal type Ia sepsis in mice after intranasal inoculation and the effect of infection on lungs.
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Group B streptococcal type Ia sepsis in mice after intranasal inoculation and the effect of infection on lungs.

机译：鼻内接种后小鼠的B组链球菌Ia型败血症及其对肺部感染的影响。

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The intranasal inoculation of adult mice with saline suspensions of virulent group B streptococci serotype Ia resulted in septicemia which was lethal. Decreasing the inoculation dose of streptotocci increased the time required for their appearance in the blood and the mean time to death of the mice. Before the appearance of septicemia, the number of organisms in the lungs decreased to about 1% of the inoculation dose, and the majority could be recovered by lavage of the lungs through the trachea. In contrast, most of the organisms remained in the lavaged lungs of bacteremic mice after intranasal or intravenous inoculation. Lung surfactant obtained from infected mice was altered by a reduction in lipid and by an increase in protein. The organisms in vitro did not attack surfactant lipid labeled with [1-14C]palmitic acid, but their pathogenesis in vivo affected the permeability of the air-blood barrier, as shown by the leakage into the air spaces of plasma albumin labeled by the intravenous injection of Evans blue dye.
机译：鼻内接种强力B型链球菌血清型Ia的生理盐水悬液导致败血症，这是致命的。降低链球菌的接种剂量会增加其在血液中出现所需的时间，并增加小鼠的平均死亡时间。在败血病出现之前，肺中的生物数量已减少到接种剂量的1％左右，大部分可以通过通过气管洗肺来恢复。相反，在鼻内或静脉内接种后，大多数生物体仍留在细菌小鼠的灌肠中。从感染小鼠获得的肺表面活性剂通过脂质减少和蛋白质增加而改变。体外生物体并未攻击用[1-14C]棕榈酸标记的表面活性剂脂质，但它们的体内发病机制影响了气血屏障的通透性，如静脉内标记的血浆白蛋白泄漏到空气空间中所示注射伊文思蓝染料。

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