• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Suppression of the intestinal immune response to cholera toxin by specific serum antibody.
【24h】

Suppression of the intestinal immune response to cholera toxin by specific serum antibody.

机译：特异性血清抗体抑制肠道对霍乱毒素的免疫反应。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The possibility that preexisting specific serum antibody could suppress a defined mucosal immune response to a topically applied antigen was studied in rats. Hyperimmune serum antibody induced by parenteral immunization of rats with cholera toxoid markedly suppressed the mucosal immune response to enterically applied cholera toxin. Such antibody was far more suppressive than antibody induced by primary parenteral immunization, apparently due to its greater avidity. Transfusion of small amounts (25 to 100 microliter) of hyperimmune serum suppressed the primary mucosal antitoxin response, the development of specific memory in the mucosal immune system, and, somewhat less effectively, the secondary mucosal antitoxin response. Suppression was due largely to a direct effect of serum antibody upon the interaction of absorbed enteric antigen with lymphoid tissue in Peyer's patches and, possible, mesenteric lymph nodes; interference with antigen absorption played little or no role in the observed suppression. These results do not explain the previously reported suppressive effect of primary parenteral immunization on the mucosal immune response to cholera toxin. However, they support the notions that repeated parenteral immunization can evoke avid serum antibody without necessarily stimulating mucosa-associated lymphoid tissue and that such antibody can markedly suppress primary and secondary phases of the local immune response to mucosally applied antigen. Thus, a mechanism is demonstrated by which repeated parenteral immunization may adversely affect efforts to initiate or sustain protective mucosal immune responses.
机译：在大鼠中研究了预先存在的特异性血清抗体可以抑制针对局部应用抗原的明确的粘膜免疫反应的可能性。肠胃外接种霍乱类毒素的大鼠产生的超免疫血清抗体显着抑制了肠溶性霍乱毒素的粘膜免疫反应。显然由于其更大的亲和力，这种抗体比通过初次肠胃外免疫诱导的抗体具有更大的抑制性。少量（25至100微升）超免疫血清的输注抑制了原发性粘膜抗毒素反应，粘膜免疫系统中特定记忆的发展，以及次要的粘膜抗毒素反应。抑制主要是由于血清抗体对吸收的肠抗原与派伊尔淋巴结和可能的肠系膜淋巴结中的淋巴样组织相互作用的直接作用。干扰抗原吸收在观察到的抑制中几乎没有作用。这些结果不能解释先前报道的初级肠胃外免疫对霍乱毒素黏膜免疫反应的抑制作用。但是，他们支持这样的观念，即反复的肠胃外免疫可以引起狂热的血清抗体，而不必刺激粘膜相关的淋巴样组织，并且这种抗体可以显着抑制对粘膜施用抗原的局部免疫反应的初级和次级阶段。因此，证明了一种机制，通过该机制反复进行肠胃外免疫可能会对启动或维持保护性粘膜免疫反应的努力产生不利影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号