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Effect of Antilymphocyte Serium on Tacaribe Virus Infection in Infant Mice

机译：抗淋巴细胞血清对婴儿小鼠塔卡里布病毒感染的影响

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Tacaribe virus, a member of the arenovirus group, was demonstrated to have similarities in pathogenesis to the prototype virus of this group, lymphocytic choriomeningitis (LCM) virus. Treatment with antilymphocyte serum (ALS) doubled the survival time of mice neonatally infected with a lethal dose of Tacaribe virus. Twenty-one per cent of ALS-treated infected animals survived more than 30 days. All animals had recoverable virus in brains and serum for the duration of life, and there was no difference between virus growth curves of ALS-treated and control animals. No neutralizing or complement-fixing antibodies were present in infected animals at time of death, with the exception of one long-surviving ALS-treated animal. Certain differences between infections of mice with LCM and Tacaribe viruses were apparent. Tacaribe virus pathogenicity decreased with increasing mouse age, and earlier infection and a more prolonged course of ALS treatment than was needed for LCM virus were necessary to achieve increased survival. Histopathological changes observed in Tacaribe virus-infected control mice were focal choroiditis and focal cerebellar necrosis; these changes were not seen in asymptomic infected mice during the period of transient protection by ALS.
机译：Tacaribe病毒是槟榔病毒组的成员，在发病机理上与该组的原型病毒淋巴细胞性脉络膜脑膜炎（LCM）病毒具有相似性。用抗淋巴细胞血清（ALS）处理可使新生的致死剂量的Tacaribe病毒感染的小鼠的存活时间增加一倍。 21％的ALS治疗感染动物存活超过30天。所有动物在整个生命过程中的大脑和血清中均具有可恢复的病毒，并且ALS处理动物和对照动物的病毒生长曲线之间没有差异。除一只长期存活的ALS治疗的动物外，死亡时感染的动物中不存在任何中和或固定抗体的抗体。 LCM和Tacaribe病毒感染小鼠之间的某些差异是显而易见的。 Tacaribe病毒的致病性随小鼠年龄的增加而降低，并且比LCM病毒需要更早的感染和更长的ALS治疗过程是增加生存率所必需的。 Tacaribe病毒感染的对照小鼠的组织病理学变化为局灶性脉络膜炎和局灶性小脑坏死。在由ALS进行的瞬时保护期间，在无症状感染的小鼠中未观察到这些变化。

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