• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Adenovirus-transformed cells restrict Herpes simplex virus replication.
【24h】

Adenovirus-transformed cells restrict Herpes simplex virus replication.

机译：腺病毒转化的细胞限制了单纯疱疹病毒的复制。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A cell line that normally supports the replication of herpes simplex virus types 1 and 2 became resistant to these viruses after transformation by simian adenovirus 7. Kinetic studies of the mechanism of resistance demonstrated that both herpesviruses were able to attach to the transformed cells and express some early genomic functions, as demonstrated by the presence of low levels of viral thymidine kinase. However, isopycnic centrifugation studies of the abortive system failed to detect viral deoxyribonucleic acid synthesis, whereas indirect immunofluorescent studies of viral proteins revealed that less than 10 per cent of the cells contained these viral macromolecules at any given time. Collectively the data suggest that after transformation by simian adenovirus 7 these cells are altered so as to render them resistant or incapable of supporting the growth of herpes simplex virus types 1 and 2. The results further suggest that the block occurs after viral absorption and prior to viral deoxyribonucleic acid synthesis.
机译：经猿猴腺病毒7转化后，通常支持1型和2型单纯疱疹病毒复制的细胞系对这些病毒产生抗药性。抗药性机理的动力学研究表明，两种疱疹病毒都能附着在转化的细胞上并表达一些早期的基因组功能，如低水平的病毒胸苷激酶的存在所证明。但是，流产系统的等温离心研究未能检测到病毒脱氧核糖核酸的合成，而对病毒蛋白质的间接免疫荧光研究表明，在任何给定时间，只有不到10％的细胞含有这些病毒大分子。总体而言，这些数据表明，经猿猴腺病毒7转化后，这些细胞发生了改变，从而使其具有抗药性或无法支持1型和2型单纯疱疹病毒的生长。结果进一步表明，这种阻断发生在病毒吸收后和病毒脱氧核糖核酸的合成。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号