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首页> 外文期刊>Infection and immunity >Passive immunity in transmissible gastroenteritis of swine: immunoglobulin characteristics of antibodies in milk after inoculating virus by different routes.
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Passive immunity in transmissible gastroenteritis of swine: immunoglobulin characteristics of antibodies in milk after inoculating virus by different routes.

机译：猪传染性胃肠炎的被动免疫：通过不同途径接种病毒后，牛奶中抗体的免疫球蛋白特征。

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Pregnant swine were exposed to transmissible gastroenteritis (TGE) virus by different routes, and their serum, colostrum, and mild were examined for titer and immunoglobulin (Ig) class of antibodies. When 2 to 4 days old, the litters of most of these animals were challenged with virulent TGE virus to determine the effectiveness of passive immunity. After two oral/intranasal exposures to attenuated virus, none of the six pregnant animals became sick. TGE antibodies in milk were primarily or solely of the IgG class, although low levels of IgA antibodies were detected in three animals. Pigs in the five challenged litters received some passive immunity, the mortality being 25%. After intramuscular injection of six pregnant swine with virulent virus, two types of clinical and immunological responses were observed, presumably dependent on whether the gut was infected by an hematogenous spread of the virus. Three became sick, showing typical clinical signs of TGE, and their immunological response was characterized by the occurrence in milk of antibodies of the IgA class. A good degree (0% mortality) of passive immunity occurred upon challenge of the suckling pigs. In contrast, in three pregnant animals that did not sicken, antibody in milk was primarily of the IgG calss, and poor (69% mortality) passive immunity occurred. After intramammary injections of three pregnant swine with virulent virus, no sickness was observed and the immunological response was characterized by the occurrence in colostrum of high titers of TGE antibodies that were primarily or solely of the IgG class; good (0% mortality) passive immunity occured. The occurrence in milk of TGE antibodies of the IgA class was associated with an intestinal infection, whereas antibodies of the IgG class resulted from a parenteral antigenic stimulation. The role of antigenic stimulation of the intestinal tract for providing antibodies in milk of the IgA class is discussed. Passive immunity against intestinal infection with TGE virus was generally more complete in pigs ingesting antibodies of the IgA than of the IgG class.
机译：怀孕的猪通过不同途径暴露于传染性胃肠炎（TGE）病毒，并检查其血清，初乳和轻度抗体的滴度和免疫球蛋白（Ig）类。当2-4天大时，用强力的TGE病毒攻击其中大多数动物的产仔，以确定被动免疫的有效性。在两次口服/鼻内减毒病毒暴露后，六只怀孕的动物都没有生病。牛奶中的TGE抗体主要或仅属于IgG类，尽管在三只动物中检测到了低水平的IgA抗体。在五个受到挑战的垫料中，猪获得了一定的被动免疫力，死亡率为25％。肌肉注射六只怀孕的猪用强毒病毒后，观察到两种类型的临床和免疫反应，大概取决于肠道是否被病毒的血源性传播所感染。三人患病，表现出典型的TGE临床症状，其免疫反应的特征是在牛奶中出现了IgA类抗体。乳猪攻击后，发生了很大程度的被动免疫（死亡率为0％）。相比之下，在三只未患病的怀孕动物中，牛奶中的抗体主要是IgG抗体，并且发生了不良免疫反应（死亡率为69％）。乳房内注射三只强毒病毒的怀孕猪后，未观察到疾病，其免疫反应的特征是初乳中出现了高滴度的TGE抗体，这些抗体主要或仅属于IgG类。发生了良好的（0％死亡率）被动免疫。牛奶中IgA类TGE抗体的出现与肠道感染有关，而IgG类抗体则是由肠胃外抗原刺激引起的。讨论了肠道抗原刺激在IgA类牛奶中提供抗体的作用。一般而言，摄入IgA抗体的猪对TGE病毒的肠道感染的被动免疫力比IgG类更完整。

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