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Complement system in pneumococcal infections.

机译：肺炎球菌感染的补体系统。

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The properdin or alternate complement pathway may function as a heat-labile opsonin for pneumococci, and evidence has been sought for its activation in pneumococcal infections. Twenty-two patients had determinations of C1q, C4, properdin factor B, C3, and hemolytic complement during hospitalization for pneumococcal infection. Measurements were made during the first 36 h after admission on 16 patients and later during recovery on 16. The admission and recovery values were compared statistically with each other and with the levels of 15 normal individuals. The admission and recovery mean values were normal and nearly identical for C1q and C4, which are two early components of the classical pathway. The mean level of factor N, a properdin pathway component, was significantly depressed on admission, but the mean recovery value was normal. Admission levels for C3, a component of the late common pathway, were depressed, and recovery values were normal. Total hemolytic complement was decreased on admission, although the decrease was not significant for the patients with both admission and recovery determinations. The findings are consistent with the hypothesis that factor B is turned over rapidly, or consumed, early in pneumococcal infections; alternatively, persons with low baseline factor B levels may be particularly susceptible to pneumococcal infection.
机译：备解素或替代补体途径可作为肺炎球菌的对热不稳定的调理素，并且已寻求其在肺炎球菌感染中活化的证据。 22名患者在住院期间因肺炎球菌感染而测定了C1q，C4，备解素B，C3和溶血补体。在入院后最初的36小时内对16位患者进行了测量，随后在16位患者的恢复期间进行了测量。将入院和恢复值彼此进行统计，并与15名正常个体的水平进行比较。 C1q和C4的入院和恢复平均值均正常，几乎相同，这是经典途径的两个早期组成部分。入选时，备解素途径成分N的平均水平显着降低，但平均恢复值是正常的。 C3（晚期常见途径的组成部分）的入院水平降低，恢复值正常。入院时总溶血补体降低，尽管对于入院和恢复测定的患者来说，总溶血补体的减少并不明显。这些发现与以下假设相符：在肺炎球菌感染早期，B因子被迅速翻转或消耗。另外，基线因子B水平低的人可能特别容易感染肺炎球菌。

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