...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Distribution of T and B lymphocytes in lymphoid tissue of infants and children.
【24h】

Distribution of T and B lymphocytes in lymphoid tissue of infants and children.

机译：T和B淋巴细胞在婴幼儿淋巴组织中的分布。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Normal lymphoid tissue from children undergoing elective surgery was examined for T and B lymphocyte distribution. Although established for peripheral blood and bone marrow, T and B lymphocyte distributions have not been previously reported for lymph nodes, appendix, thymus, and spleen tissues in children. Thymus-dependent T cells were determined by the sheep erythrocyte rosette technique, and thymus-independent B cells were determined by the fluorescent labeling of surface immunoglobulins A (IgA), G (IgG), and M (IgM). Fifty percent of lymph node cells were either T or B cells; 65% of these cells were T lymphocytes, whereas 58% of B cells were of the IgM subclass. Less than half of the appendix cells were either T or B cells; 47% of these were T lymphocytes, and the remainder B lymphocytes had subclass distribution similar to that of lymph nodes but different from peripheral blood and bone marrow where B cells bearing IgG predominate. Thymus tissue contained 43% T cells and less than 1% B cells, but the spleen was composed largely of B cells, predominantly of the IgM type. Lymphoid tissue from nine children with either inflammatory or neoplastic diseases were studied and included for contrast. This paper establishes relative distribution values for T and B lymphocytes in normal lymphoid tissue and points out the potential use of this technique to quantitate deviations from normal in certain inflammatory and neoplastic diseases.
机译：检查接受择期手术的儿童的正常淋巴组织的T和B淋巴细胞分布。尽管针对外周血和骨髓建立了T和B淋巴细胞分布，但先前尚未报道儿童淋巴结，阑尾，胸腺和脾脏组织的T和B淋巴细胞分布。通过绵羊红细胞玫瑰花结技术确定胸腺依赖性T细胞，并通过表面免疫球蛋白A（IgA），G（IgG）和M（IgM）的荧光标记确定胸腺非依赖性B细胞。 50％的淋巴结细胞是T细胞或B细胞。这些细胞中有65％是T淋巴细胞，而B细胞中有58％是IgM亚类。少于一半的阑尾细胞是T细胞或B细胞;这些淋巴细胞中有47％是T淋巴细胞，其余的B淋巴细胞具有与淋巴结相似的亚类分布，但与携带IgG的B细胞占优势的外周血和骨髓不同。胸腺组织含有43％的T细胞和少于1％的B细胞，但脾脏主要由B细胞组成，主要是IgM型。研究了来自9名患有炎性或肿瘤性疾病的儿童的淋巴组织，并将其作为对比。本文建立了正常淋巴组织中T和B淋巴细胞的相对分布值，并指出了该技术在某些炎性和赘生性疾病中可能用于定量偏离正常值的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号