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首页> 外文期刊>Infection and immunity >Effect of rheumatoid factor and anti-immunoglobulin G antibodies on complement-mediated lysis of herpes simplex virus-infected human fibroblasts.
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Effect of rheumatoid factor and anti-immunoglobulin G antibodies on complement-mediated lysis of herpes simplex virus-infected human fibroblasts.

机译：类风湿因子和抗免疫球蛋白G抗体对单纯疱疹病毒感染的人类成纤维细胞补体介导的裂解的影响。

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摘要

The effect of various anti-immunoglobulin G (IgG) antibodies on the complement-mediated lysis of herpes simplex virus-infected human fibroblasts was determined. IgM rheumatoid factor, a naturally occurring anti-human Fc, inhibited lysis, whereas rabbit anti-human IgG serum potentiated immune cytolysis. We attempted to explain this disparity by determining the effect various classess of anti-IgG's with differing specificities had on complement-mediated lysis. Inhibition of cytolysis occurred with IgM anti-Fc and all of the IgG antiglobulins (anti-IgG, Fab, and Fc). In contrast, IgM anti-Fab enhanced lysis. IgM anti-IgG suppressed immune cytolysis when high concentrations of antiviral serum were incubated with the virus-infected cell, but augmented lysis when low concentrations of anti-herpes simplex virus antibody were exposed to the fibroblasts. The experiments indicated that whether a particular antiglobulin potentiates or inhibits lysis depends on the concentration of antibody bound to the target cells as well as the class and specificity of the antiglobulin exposed to the antibody-coated cell.
机译：确定了各种抗免疫球蛋白G（IgG）抗体对补体介导的单纯疱疹病毒感染的人成纤维细胞裂解的影响。 IgM类风湿因子（一种天然存在的抗人Fc）可抑制裂解，而兔抗人IgG血清可增强免疫细胞溶解。我们试图通过确定具有不同特异性的各种类型的抗IgG对补体介导的裂解的影响来解释这种差异。 IgM抗Fc和所有IgG抗球蛋白（抗IgG，Fab和Fc）均发生细胞溶解抑制作用。相反，IgM抗-Fab增强了裂解。当高浓度的抗病毒血清与病毒感染的细胞一起孵育时，IgM抗IgG抑制了免疫细胞溶解，但当低浓度的抗单纯疱疹病毒抗体暴露于成纤维细胞时，IgM抗IgG的溶解增加。实验表明，特定的抗球蛋白是增强还是抑制裂解取决于与靶细胞结合的抗体浓度，以及暴露于抗体包被的细胞的抗球蛋白的种类和特异性。

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