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首页> 外文期刊>Infection and immunity >Antigenic properties of human lymphoblastoid interferons.
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Antigenic properties of human lymphoblastoid interferons.

机译：人淋巴母细胞干扰素的抗原特性。

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摘要

Most virus-induced human lymphoblastoid interferons examined contained variable proportions of the Le and F antigenic species described for human leukocyte interferon. The F species was not detectable in interferons liberated spontaneously from human lymphoblastoid cells in culture. Lymphoblastoid interferons differed considerably in their interaction with the same anti-interferon serum. Spontaneous interferons required approximately ten times less antibody for neutralization than interferon induced by virus in the same cultures or in Namalva cells. The findings suggest that either spontaneous interferons contain fewer inactive antibody-binding molecules than virus-induced lymphoblastoid interferons or the number and distribution of antibody-combining sites, and possibly other surface properties of the interferon molecule, may be influenced by the manner in which spontaneous and induced interferons egress from the cells.
机译：检查的大多数病毒诱导的人类淋巴母细胞干扰素均含有不同比例的针对人类白细胞干扰素的Le和F抗原物种。在培养的人淋巴母细胞自发释放的干扰素中未检测到F物种。淋巴母细胞干扰素与相同的抗干扰素血清的相互作用差异很大。在相同培养物中或在纳马尔瓦细胞中，自发干扰素所需的抗体被中和的剂量比病毒诱导的干扰素少约十倍。研究结果表明，自发干扰素所含的无活性抗体结合分子比病毒诱导的淋巴母细胞干扰素要少，或者抗体结合位点的数量和分布以及干扰素分子的其他表面性质可能受自发干扰方式影响。并诱导干扰素从细胞中逸出。

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