Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis.

H L Walker; C G McLeod; S H Leppla; A D Mason

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Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis.

机译：铜绿假单胞菌毒素A在实验性大鼠烧伤创面败血症中的评估。

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The search for methods to achieve control of Pseudomonas aeruginosa infection continues with the introduction of aluminum-absorbed toxoid developed from P. aeruginosa exotoxin. This toxoid induces significant titers of neutralizing and precipitating antibodies for toxin A when given with appropriate adjuvants. These experiments show that immunization with aluminum phosphate-absorbed toxoid failed to protect burned rats infected with P. aeruginosa. These and previous experiments show that active immunization with live P. aeruginosa provides good strain-specific protection in the same model. No cross-protection was demonstrated between strains of P. aeruginosa in these experiments.

机译：通过引入由铜绿假单胞菌外毒素开发的铝吸收类毒素，继续寻求控制铜绿假单胞菌感染的方法。当与适当的佐剂一起使用时，该类毒素会诱导明显的滴度，以中和沉淀出毒素A的抗体。这些实验表明，用磷酸铝吸附的类毒素免疫不能保护被铜绿假单胞菌感染的烧伤大鼠。这些和以前的实验表明，在同一模型中，以活铜绿假单胞菌进行主动免疫可提供良好的菌株特异性保护。在这些实验中，没有证明铜绿假单胞菌菌株之间有交叉保护。

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《Infection and immunity》 |1979年第3期|共3页
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H L Walker; C G McLeod; S H Leppla; A D Mason;
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中图分类医学免疫学;
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1. Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis. [J] . H L Walker, C G McLeod, S H Leppla, Infection and immunity . 1979,第3期

机译：铜绿假单胞菌毒素A在实验性大鼠烧伤创面败血症中的评估。
2. Passive immunisation against Pseudomonas aeruginosa recombinant flagellin in an experimental model of burn wound sepsis. [J] . Faezi S, Sattari M, Mahdavi M, Burns: Including Thermal Injury . 2011,第5期

机译：在烧伤脓毒症的实验模型中针对铜绿假单胞菌重组鞭毛蛋白的被动免疫。
3. Histopathological comparisons of Staphylococcus aureus and Pseudomonas aeruginosa experimental infected porcine burn wounds [J] . Chaney Sarah B., Ganesh Kasturi, Mathew-Steiner Shomita, Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society . 2017,第3期

机译：金黄色葡萄球菌和假单胞菌铜绿假单胞菌实验感染猪烧伤的组织病理学比较
4. Prevention of bloodstream infections by photodynamic inactivation of multi-resistant Pseudomonas aeruginosa in burn wounds [C] . M. C. E. Hashimoto, R. A. Prates, D.J. Toffoli, Mechanisms for low-light therapy V . 2010

机译：通过光动力灭活烧伤创面中的多抗性铜绿假单胞菌来预防血液感染
5. Enzymatic Depletion of Pyruvate using Pyruvate Dehydrogenase Induces Dispersion of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms and Poses a Potentially Powerful Anti-Biofilm Treatment Strategy for Chronic Burn Wound Infections [D] . Goodwine, James Stephen. 2018

机译：使用丙酮酸脱氢酶诱导丙酮酸丙酮酸的酶促耗尽铜绿假单胞菌和金黄色葡萄球菌生物膜的分散，并为慢性烧伤伤口感染造成潜在强效的抗生物膜处理策略
6. Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis. [O] . H L Walker, C G McLeod Jr, S H Leppla, 1979

机译：铜绿假单胞菌毒素A在实验性大鼠烧伤创面败血症中的评估。
7. Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis [O] . H L Walker, C G McLeod, S H Leppla, 1979

机译：实验大鼠烧伤伤口脓毒症铜绿假单胞菌毒素A的评价

Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis.

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