Effect of β-3-Thienylalanine on Antibody Synthesis V. Immunosuppression in Mice by Short Diet and Drug Treatments

Aldo Misefari; Mariano F. La Via

首页> 外文期刊>Infection and immunity >Effect of β-3-Thienylalanine on Antibody Synthesis V. Immunosuppression in Mice by Short Diet and Drug Treatments

【24h】

Effect of β-3-Thienylalanine on Antibody Synthesis V. Immunosuppression in Mice by Short Diet and Drug Treatments

机译：短期饮食和药物治疗对β-3-噻吩丙氨酸对小鼠抗体合成V.免疫抑制的影响

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The analogue of phenylalanine, β-3-thienylalanine, depresses severely the primary and secondary immune response to sheep erythrocytes in mice when administered for a few days immediately before and after each injection of antigen. For this immunosuppression to occur, animals must be maintained on a phenylalanine-free diet during the times of drug injection since dietary phenylalanine will restore anamnestic response. With these experimental conditions, the number of direct and indirect plaque-forming cells is greatly reduced during immune responses. The finding that marked immunosuppression can be obtained with a very short drug and diet treatment points to a potential usefullness of the analogue as a powerful immunosuppressant.

机译：每次注射抗原前后数天，苯丙氨酸类似物β-3-噻吩丙氨酸会严重抑制小鼠对绵羊红细胞的初次和二次免疫反应。为了进行这种免疫抑制，在药物注射期间必须使动物保持无苯丙氨酸饮食，因为饮食中的苯丙氨酸会恢复记忆消除。在这些实验条件下，免疫应答过程中直接和间接噬菌斑形成细胞的数量大大减少。可以用非常短的药物和饮食治疗获得明显的免疫抑制的发现，表明该类似物作为强力免疫抑制剂具有潜在的实用性。

著录项

来源
《Infection and immunity》 |1971年第3期|共5页
作者
Aldo Misefari; Mariano F. La Via;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Effect of β-3-Thienylalanine on Antibody Synthesis IV. Suppression of the Immune Response in Mice [J] . Aldo Misefari, Mariano F. La Via Infection and immunity . 1971,第6期

机译：β-3-噻吩丙氨酸对抗体合成的影响IV。小鼠免疫反应的抑制
2. Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression. [J] . Roether S, Rabbani H, Mellstedt H, Scandinavian journal of immunology. . 2002,第5期

机译：长期暴露于氯化汞后，易感小鼠中抗体/自身抗体合成的自发下调不是由于普遍的免疫抑制。
3. Treatment with Anti-Interleukin-6 Receptor Antibody Ameliorates Intestinal Polyposis in Apc(Min/+) Mice under High-Fat Diet Conditions [J] . Yaoita Takao, Sasaki Yu, Yokozawa Junji, The Tohoku Journal of Experimental Medicine . 2015,第2期

机译：抗白介素6受体抗体治疗可减轻高脂饮食条件下Apc（Min / +）小鼠的肠道息肉病
4. Synthesis and characterization of copolymeric micelles loaded with Taxol as potential drug delivery systems for cancer treatment [C] . L. V. Tapia, J. S. Castro, C. A. Martinez, Materials Research Society Meeting . 2011

机译：用紫杉醇作为癌症治疗潜在药物递送系统的共聚物胶束的合成与表征
5. A SURVEY STUDY OF DRUG AND NON-DRUG MANAGEMENTS FOR THE HYPERACTIVE CHILD: TREATMENT PREFERENCES OF PARENTS, TEACHERS, SPECIAL EDUCATION PERSONNEL AND PHYSICIANS (DIET, PSYCHOTHERAPY, MULTIDISCIPLINARY, BEHAVIOR MODIFICATION). [D] . MORRIS, GEORGE E. 1985

机译：对过动儿童的药物和非药物管理调查研究：父母，教师，特殊教育人员和医生（饮食，心理治疗，多学科，行为改变）的治疗偏好。
6. Effect of β-3-Thienylalanine on Antibody Synthesis V. Immunosuppression in Mice by Short Diet and Drug Treatments [O] . Aldo Misefari, Mariano F. La Via 1971

机译：短期饮食和药物治疗对β-3-噻吩丙氨酸对小鼠抗体合成V.免疫抑制的影响
7. Effect of β-3-Thienylalanine on Antibody Synthesis IV. Suppression of the Immune Response in Mice [O] . Aldo Misefari, Mariano F. La Via 1971

机译：β-3-噻吩氨基碱对抗体合成IV的影响。抑制小鼠免疫应答

Effect of β-3-Thienylalanine on Antibody Synthesis V. Immunosuppression in Mice by Short Diet and Drug Treatments

摘要

著录项

相似文献

相关主题

期刊订阅