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Neutralizing Antibodies to Cytomegaloviruses in Normal Simian and Human Sera

机译:正常猿猴和人血清中巨细胞病毒的中和抗体

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Simian and human sera were examined for neutralizing antibodies to simian and human cytomegaloviruses (CMV). Neutralizing antibody to simian CMV was found in sera from 12 of 12 African green monkeys, 8 of 10 rhesus monkeys, and 7 of 7 baboons captured in the wild. The antibody did not cross-react with human CMV strain AD169 but cross-reacted with human strain C87, particularly in the presence of complement. Thirty-six baboons and 10 rhesus monkeys born and hand-reared in captivity remained free of neutralizing antibody both to simian and human CMV for as long as 4 years. Fifteen of 24 human sera (63%) revealed only species-specific neutralizing antibody.
机译:检查了猿猴和人血清的猿猴和人巨细胞病毒(CMV)中和抗体。在野外捕获的12只非洲绿猴中的12只,10只恒河猴中的8只和7只狒狒中的7只的血清中发现了针对猿猴CMV的中和抗体。该抗体不会与人CMV株AD169交叉反应,但会与人C87株交叉反应,特别是在存在补体的情况下。圈养了36只狒狒和10只恒河猴,人工饲养的它们在长达4年的时间内都没有中和抗体。 24个人血清中有15个(63%)仅显示物种特异性中和抗体。

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