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Effects of Promethazine-Hydrochloride on Human Polymorphonuclear Leukocytes

机译：盐酸异丙嗪对人多形核白细胞的影响

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摘要

Promethazine hydrochloride at a concentration of 0.033 mg/ml has pronounced effects on leukocyte metabolism and function. The drug inhibits the phagocytosis-induced increases in O2 consumption and hexose monophosphate shunt activity. Associated with these effects is an inhibition of the iodination of zymosan particles and an inhibition of bacterial killing by the cell. At least two mechanisms appear to be involved. Many of the effects can be explained by an inhibition of phagocytosis, but promethazine also inhibits the decarboxylation of amino acids and iodide fixation in a cell-free system, indicating a specific effect on metabolism. These results may partially account for the action of the drug in ameliorating the effects of erythroblastosis.
机译：浓度为0.033 mg / ml的盐酸异丙嗪对白细胞代谢和功能有明显影响。该药物抑制吞噬作用诱导的O 2 消耗量增加和己糖一磷酸分流活性。与这些作用有关的是抑制酵母聚糖颗粒的碘化和抑制细菌被细胞杀死。似乎涉及至少两种机制。许多作用可以通过抑制吞噬作用来解释，但是异丙嗪还可以抑制无细胞系统中氨基酸的脱羧和碘化物的固定，表明对代谢具有特定作用。这些结果可能部分解释了药物在改善成红细胞病作用方面的作用。

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