Mechanism of Adherence of Streptococcus mutans to Smooth Surfaces I. Roles of Insoluble Dextran-Levan Synthetase Enzymes and Cell Wall Polysaccharide Antigen in Plaque Formation

Hidehiko Mukasa; Hutton D. Slade

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Mechanism of Adherence of Streptococcus mutans to Smooth Surfaces I. Roles of Insoluble Dextran-Levan Synthetase Enzymes and Cell Wall Polysaccharide Antigen in Plaque Formation

机译：变形链球菌粘附于光滑表面的机理I.不溶性葡聚糖-Levan合成酶和细胞壁多糖抗原在菌斑形成中的作用

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The mechanism of adherence of Streptococcus mutans to smooth glass surfaces has been studied. The results with both viable and heat-killed cells showed that the process required (i) the synthesis of a water-insoluble dextran-levan polymer by cell-bound enzymes and (ii) the participation of a binding site on the surface of the S. mutans cell. Synthesis of the polymer from sucrose in the presence of the cells was required for adherence, and indicates that an “active” form of the polymer was required. Polymer synthesized by cell-free S. mutans enzymes when added to S. mutans cells did not produce adherence. Purified antibody globulin, specific for the a-d site in the polysaccharide S. mutans group a antigen, completely inhibited adherence. Antibody to the second antigen present in the polysaccharide molecule, the a antigen, did not inhibit adherence. The evidence indicates that adherence did not require an antigenic binding site which might be common to all S. mutans strains. The orientation of the synthetase enzyme(s), antigenic binding site, and dextran-levan polymer on the cell surface is under study.

机译：研究了变形链球菌对光滑玻璃表面的粘附机理。活细胞和热杀死细胞的结果表明，该过程需要（i）通过细胞结合酶合成水不溶性右旋糖酐-左旋聚合物，以及（ii）结合表面上结合位点的参与。 em> S。变形细胞。粘附需要从蔗糖在细胞存在下合成聚合物，这表明需要“活性”形式的聚合物。通过无细胞的em合成的聚合物。添加到 S中的变异酶。变形细胞不产生粘附。纯化的抗体球蛋白，对多糖 S中的a-d位点具有特异性。 mutans 组a抗原，完全抑制粘附。存在于多糖分子中的第二抗原的抗体，即α抗原，不抑制粘附。证据表明，粘附不需要所有 S可能共有的抗原结合位点。变形株。合成酶，抗原结合位点和葡聚糖-左旋聚合物在细胞表面的取向正在研究中。 展开▼

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《Infection and immunity》 |1973年第4期|共8页

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Hidehiko Mukasa; Hutton D. Slade;
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中图分类医学免疫学;

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1. Mechanism of Adherence of Streptococcus mutans to Smooth Surfaces II. Nature of the Binding Site and the Adsorption of Dextran-Levan Synthetase Enzymes on the Cell-Wall Surface of the Streptococcus [J] . Hidehiko Mukasa, Hutton D. Slade Infection and immunity . 1974,第2期

机译：变形链球菌粘附于光滑表面的机理II。链球菌的细胞壁表面上结合位点的性质和右旋糖酐合成酶的吸附

2. Mechanism of the Adherence of Streptococcus mutans to Smooth Surfaces III. Purification and Properties of the Enzyme Complex Responsible for Adherence [J] . Hidehiko Mukasa, Hutton D. Slade Infection and immunity . 1974,第5期

机译：变形链球菌粘附于光滑表面的机理III。负责粘附的酶复合物的纯化和性质

3. Independence of water‐insoluble glucan synthesis and adherence of Streptococcus mutans to smooth surfaces [J] . Fukushima Kazuo, Ikeda Tadashi, Motoda Ryuichi, FEBS Letters . 1982,第2期

机译：水不溶性葡聚糖合成的独立性和变形链球菌对光滑表面的粘附

4. Influence of Cell Wall Polysaccharides on Structure and Mechanics of Streptococcus mutans [C] . Joree N. Sandin, Natalia Korotkova, Martha E. Grady SEM Annual Conference and Exposition on Experimental and Applied Mechanics . 2020

机译：细胞壁多糖对链球菌结构和力学的影响

5. Study of the physiological and molecular mechanisms underlying peptide-induced cell death and biofilm formation in Streptococcus mutans. [D] . Perry, Julie Ann. 2009

机译：变形链球菌中肽诱导的细胞死亡和生物膜形成的生理和分子机制研究。

6. Mechanism of Adherence of Streptococcus mutans to Smooth Surfaces I. Roles of Insoluble Dextran-Levan Synthetase Enzymes and Cell Wall Polysaccharide Antigen in Plaque Formation [O] . Hidehiko Mukasa, Hutton D. Slade 2007

机译：变形链球菌粘附于光滑表面的机制I.不溶性葡聚糖-Levan合成酶和细胞壁多糖抗原在菌斑形成中的作用

7. Mechanism of Adherence of Streptococcus mutans to Smooth Surfaces II. Nature of the Binding Site and the Adsorption of Dextran-Levan Synthetase Enzymes on the Cell-Wall Surface of the Streptococcus [O] . Hidehiko Mukasa, Hutton D. Slade 1974

机译：链球菌变形对光滑表面II的机制II。结合位点的性质和葡聚糖-Levan合成酶对链球菌细胞壁表面上的吸附

8. Isolation of a Coaggregation-Inhibiting Cell Wall Polysaccharide from Streptococcus sanguis H1. (Reannouncement with New Availability Information). [R] . Cassels, F. J., London, J. 1989

机译：从血链球菌H1中分离抑制聚集的细胞壁多糖。（重新公布新的可用性信息）。

1. 非水溶性葡聚糖水解酶在控制人牙菌斑形成中的作用 [J] . 何国华 ,许华 . 口腔医学纵横 . 1993,第004期

1. ENZYME FOR DISSOLVING A CELL WALL OF STREPTOCOCCUS MUTANS AND MICROORGANISMS FOR PRODUCING THE ENZYME [P] . 外国专利： KR0175495B1 . 1999-02-01

机译：溶解链球菌突变体细胞壁的酶和生产该酶的微生物

2. A dissolution enzyme which dissolves the cell wall of Streptococcus mutans, a causative bacteria of dental caries, and a microorganism [P] . 外国专利： KR970074929A . 1997-12-10

机译：一种溶解酶，可溶解变形链球菌的细胞壁，龋齿的致病细菌和微生物

3. Soluble enzymes that dissolve the cell walls of Streptococcus mutans and their production microorganisms [P] . 外国专利： KR970070197A . 1997-11-07

机译：溶解变形链球菌及其产生微生物的细胞壁的可溶性酶

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Mechanism of Adherence of Streptococcus mutans to Smooth Surfaces I. Roles of Insoluble Dextran-Levan Synthetase Enzymes and Cell Wall Polysaccharide Antigen in Plaque Formation

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