Detection and Characterization of Defective Mycoplasmacidal Antibody Produced by Rodents Against Mycoplasma arthritidis

B. C. Cole; J. R. Ward

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Detection and Characterization of Defective Mycoplasmacidal Antibody Produced by Rodents Against Mycoplasma arthritidis

机译：鼠支原体支原体产生的缺陷型支原体酸性抗体的检测与鉴定

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A procedure has been developed for the detection of mycoplasmacidal antibody in the serum of rats and mice infected with Mycoplasma arthritidis. Antibody activity can apparently be measured only by using resting mycoplasma cells. The reaction is complement dependent and is usually complete within 3 h. Early antibody (5 days) could be detected only within the immunoglobulin (Ig)M fraction, whereas late antibody (42 days) is found within the IgG fraction. The mycoplasmacidal antibody was highly specific and cross reactions were not observed with other mycoplasma species. Antibody activity could be removed from serum by absorption with either viable or nonviable M. arthritidis. Cidal antibody produced by rats against other mycoplasma species was active against both resting and multiplying cells. Mycoplasmacidal antibody against M. arthritidis was detected in rats 2 days after injection of the organisms and persisted at least through 300 days. Mice usually developed antibodies by 3 days after injection of the organisms and moderate titers have been observed for as long as 487 days. Since viable mycoplasmas can persist in the peripheral circulation in the presence of antibody, it is likely that viable mycoplasma-antibody complexes are also present.

机译：已经开发了一种检测感染了支原体的大鼠和小鼠血清中支原体酸性抗体的方法。显然，只有使用静止的支原体细胞才能测定抗体的活性。反应取决于补体，通常在3小时内完成。早期抗体（5天）只能在免疫球蛋白（Ig）M部分中检测到，而晚期抗体（42天）则在IgG部分中检测到。支原体酸性抗体具有高度特异性，未与其他支原体物种发生交叉反应。可以通过用有活力或无活力的 M吸收从血清中去除抗体活性。大鼠产生的针对其他支原体物种的杀灭性抗体对静止细胞和增殖细胞均具有活性。抗 M的支原体酸性抗体。注射生物体后2天，在大鼠中检测到关节炎，并持续至少300天。小鼠通常在注射生物体后3天就会产生抗体，并且观察到中效价长达487天。由于活的支原体可以在存在抗体的情况下持续存在于外周循环中，因此也可能存在活的支原体-抗体复合物。 展开▼

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《Infection and immunity》 |1973年第2期|共9页

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B. C. Cole; J. R. Ward;
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专利

1. Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells. [J] . S M Friedman, M K Crow, J R Tumang, The Journal of Experomental Medicine . 1991,第4期

机译：与关节炎支原体源性超抗原（MAM）反应的人类T细胞的特征：产生抗V beta 17的单克隆抗体，该抗体由大部分MAM反应性人类T细胞表达。

2. Detection of Antibodies Produced in Quails (Coturnix coturnixjaponica) against Mycoplasma gallisepticum with Different Serological Tests [J] . Süheyla TüRKYILMAZ, Fethiye COVEN, Seza ESKHZMlRLILER Turkish Journal of Veterinary and Animal Sciences . 2007,第4期

机译：使用不同的血清学检测方法检测鹌鹑（Coturnix coturnixjaponica）产生的针对鸡败血支原体的抗体

3. Characterization of N-Linked Glycosylation in a Monoclonal Antibody Produced in NS0 Cells Using Capillary Electrophoresis with Laser-Induced Fluorescence Detection [J] . Melissa Hamm, Richard R. Rustandi, Yang Wang Pharmaceuticals . 2013,第3期

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4. Flash FEOL Edge Defectivity -- Ultra Thin CoxSiy Fiber Defectivity Detection, Characterizations, Root Cause Identification and Fixes to Eliminate Failures at Sort Yield [C] . Pressley, L., Meyer, . 2006

机译：Flash FEOL边缘缺陷度-超薄CoxSiy光纤缺陷度检测，表征，根本原因识别和解决方法，以消除排序良率上的故障

5. APPLICATION OF HYBRIDOMA TECHNIQUES IN DIAGNOSING PLANT PATHOGENIC SPIROPLASMAS AND MYCOPLASMAS (MONOCLONAL ANTIBODIES, ELISA, IMMUNOFLUORESCENT STAIN, DISEASE DETECTION, MLO). [D] . LIN, CHAN-PIN. 1985

机译：杂交技术在诊断植物病原性螺旋体和支原体中的应用（单克隆抗体，ELISA，免疫荧光染色，疾病检测，MLO）。

6. Detection and Characterization of Defective Mycoplasmacidal Antibody Produced by Rodents Against Mycoplasma arthritidis [O] . B. C. Cole, J. R. Ward 1973

机译：啮齿类动物支原体产生的缺陷性支原体酸性抗体的检测与鉴定

7. Detection and Characterization of Defective Mycoplasmacidal Antibody Produced by Rodents Against Mycoplasma arthritidis [O] . B. C. Cole, J. R. Ward 1973

机译：啮齿动物对骨杆菌的缺陷缺陷的MycoplasmataL抗体抗体的检测与表征

8. Preparation of Mycoplasma Seed Antigen, Antiserum, and Fluorescein Labeled Antibody Reagents and Conduct of a Mycoplasma Detection and Identification Service [R] . Carski, T. R., Robillard, N. F., Delgiudice, R. A. 1969

机译：支原体种子抗原，抗血清和荧光素标记抗体试剂的制备及支原体检测和鉴定服务的实施

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6. 肺炎支原体抗体检测在儿童支原体肺炎诊治中的应用 [C] . 李扬威 . 2007年全国深部真菌与细菌感染性疾病诊疗新进展(大连)学术研讨会 . 2007

7. 猪肺炎支原体抗原定量ELISA检测方法的建立及猪鼻支原体单克隆抗体的鉴定 [A] . 田瑞雨 . 2017

1. 用于同时检测解脲支原体、人型支原体和生殖器支原体的组合物和试剂盒 [P] . 中国专利： CN101824471B . 2012.12.12

2. 用于同时检测解脲支原体、人型支原体和生殖器支原体的组合物和试剂盒 [P] . 中国专利： CN101824471A . 2010-09-08

3. rodent, isolated rodent cell or tissue, immortalized cell, rodent embryonic stem cell, rodent embryo, and methods for producing a rodent and an antibody [P] . 外国专利： BR112018014250A2 . 2018-12-18

机译：啮齿动物，分离的啮齿动物细胞或组织，永生细胞，啮齿动物胚胎干细胞，啮齿动物胚胎，以及生产啮齿动物和抗体的方法

4. rodent, isolated rodent cell, and methods of producing a rodent and an antibody in a rodent. [P] . 外国专利： BR112019008675A2 . 2019-07-09

机译：啮齿动物，分离的啮齿动物细胞，以及在啮齿动物中产生啮齿动物和抗体的方法。

5. ARGININA DEIMINASA DERIVED FROM MYCOPLASMA ARTHRITIDIS AND CONJUGATES OF POLYMERS THAT CONTAIN IT. [P] . 外国专利： ES2255147T3 . 2006-06-16

机译：源自细支气管关节炎和含有其的聚合物共轭物的精氨酸。

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Detection and Characterization of Defective Mycoplasmacidal Antibody Produced by Rodents Against Mycoplasma arthritidis

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