Evaluation of a live, attenuated recombinant influenza vaccine in high school children.

G M Schiff; C C Linnemann; L shea; B Lange; T Rotte

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Evaluation of a live, attenuated recombinant influenza vaccine in high school children.

机译：对高中儿童的减毒活重组流感疫苗的评估。

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A live, attenuated, recombinant influenza vaccine (Alice strain) administered intranasally was evaluated in high school students and compared with intranasal placebo and subcutaneous, inactivated, bivalent influenza vaccine. The Alice strain was antigenic, increasing the geometric mean titer (GMT) from a prestudy level of 30.2 to a postvaccine level of 189.6. The inactivated vaccine increased the GMT from 32.9 to 361.8. There was no increase in the GMT among the placebo recipients. The Alice strain produced little reaction. With an antigenic, safe, acceptable, live, attenuated influenza vaccine available, immunization on a widespread basis should be considered.

机译：在高中生中评估了经鼻内施用的减毒活重组流感疫苗（Alice株），并与鼻内安慰剂和皮下灭活的二价流感疫苗进行了比较。 Alice菌株具有抗原性，将几何平均滴度（GMT）从研究前的30.2增加到疫苗接种后的189.6。灭活疫苗使GMT从32.9提高到361.8。安慰剂接受者的GMT没有增加。爱丽丝菌株几乎没有反应。有了可用的抗原性，安全性，可接受性，减毒活疫苗，应考虑广泛免疫。

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《Infection and immunity》 |1975年第4期|共4页
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G M Schiff; C C Linnemann; L shea; B Lange; T Rotte;
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1. Evaluation of a live, attenuated recombinant influenza vaccine in high school children. [J] . G M Schiff, C C Linnemann, L shea, Infection and immunity . 1975,第4期

机译：对高中儿童的减毒活重组流感疫苗的评估。
2. Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children. [J] . Levin MJ, Song LY, Fenton T, Vaccine . 2008,第33期

机译：向感染了HIV的儿童服用减毒和灭活的三价流感活疫苗后，活疫苗病毒的脱落，相对安全性和流感特异性抗体反应。
3. Randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (RELATIVES) cluster randomized trial: Pilot results from a household surveillance study to assess direct and indirect protection from influenza vaccination [J] . Kwong Jeffrey C., Pereira Jennifer A., Quach Susan, Vaccine . 2015,第38期

机译：学校减毒活疫苗和灭活流感疫苗的随机评估（RELATIVES）整群随机试验：一项家庭监测研究的初步结果，以评估对流感疫苗的直接和间接防护
4. Vaccine efficacy of live-attenuated virus, whole-virus inactivated and alphavirus vectored subunit vaccines against antigenically distinct H3N2 swine influenza A viruses [C] . Eugenio J. Abente, Nicola S. Lewis, Mark A. Mogler, Annual^Meeting of the American^Association^of^Swine^Veterinarians. . 2016

机译：活病毒的疫苗疗效，全病毒灭活和alphavirus向量亚单位疫苗反对抗原性不同的H3N2猪流感病毒
5. Influenza virus noninfectious biologically active particle subpopulations: Detection, quantification, genetic complexity, function and their novel use as an in vitro screen for self-adjuvating live-attenuated influenza vaccines. [D] . Ngunjiri, John Muthumbi. 2012

机译：流感病毒非感染性生物活性颗粒亚群：检测，定量，遗传复杂性，功能及其作为自筛选减毒活流感疫苗的体外筛选的新用途。
6. Evaluation of a live attenuated recombinant influenza vaccine in high school children. [O] . G M Schiff, C C Linnemann Jr, L shea, 1975

机译：评价高中儿童的减毒活重组流感疫苗。
7. Randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (RELATIVES) cluster randomized trial: Pilot results from a household surveillance study to assess direct and indirect protection from influenza vaccination [O] . Kwong Jeffrey C., Pereira Jennifer A., Quach Susan, 2015

机译：学校减毒活疫苗和灭活流感疫苗的随机评估（RELATIVES）整群随机试验：一项家庭监测研究的初步结果，以评估对流感疫苗的直接和间接防护
8. Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-Like Illness among US Service Members, 2006-2009. [R] . Phillips, C. J., Woolpert, T., Sevick, C., 2012

机译：2006 - 2009年美国服务成员中三价灭活流感疫苗和活减毒流感疫苗预防流感样疾病的效果比较。

Evaluation of a live, attenuated recombinant influenza vaccine in high school children.

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