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首页> 外文期刊>Infection and immunity >Coccidioidin and merthiolate in previously sensitized animals.
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Coccidioidin and merthiolate in previously sensitized animals.

机译：先前致敏的动物中的球孢菌素和硫醇盐。

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摘要

The effect of merthiolate, which is used as a preservative in skin test materials, on skin test reactions was determined in guinea pigs. In four groups of animals, merthiolate in basal medium produced skin tests at 24 and 48 h characterized by erythema and/or induration in an intermediate region, i.e., 5 plus or minus 2.2 mm. One of the four groups of animals was a nonsensitized control group. The other three groups were subcutaneously sensitized with (i) merthiolate and saline, (ii) killed Coccidioides immitis arthrospores, and (iii) merthiolate with killed C. immitis arthrospores. Coccidioidin only and merthiolate in coccidioidin produced positive delayed results in groups 3 and 4, which were sensitized with arthrospores. A synergistic effect of merthiolate and coccidioidin was observed in animals of group 4 sensitized by merthiolate with killed C. immitis arthrospores. This effect was observed at 24 h when positive reactions of coccidioidin with merthiolate were significantly greater than skin tests with plain coccidioidin.
机译：在豚鼠中确定了硫醇盐（用作皮肤测试材料的防腐剂）对皮肤测试反应的影响。在四组动物中，基础培养基中的硫醇盐在24和48小时产生皮肤测试，其特征在于中间区域即5个正负2.2 mm的红斑和/或硬结。四组动物之一是非致敏对照组。其他三组分别用（i）硫醇盐和盐水，（ii）杀灭的球虫球菌性关节炎孢子和（iii）灭硫的球孢子虫的关节炎孢子皮下致敏。仅球孢菌素和球孢菌素中的硫柳汞在第3组和第4组产生了积极的延迟结果，而第3组和第4组被节孢子致敏。在第4组的动物中观察到了硫柳汞与球孢菌素的协同作用，该动物在被硫柳汞致死的C.炎性关节炎孢子致敏。在24小时内观察到了这种效果，当球蛋白与硫醇盐的阳性反应显着大于普通球蛋白的皮肤试验时。

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