New adjuvants on a polymethylmethacrylate base.

J Kreuter; P P Speiser

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New adjuvants on a polymethylmethacrylate base.

机译：以聚甲基丙烯酸甲酯为基础的新助剂。

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A new type of adjuvant using influenza virus as an antigen is presented. The new adjuvant was produced by polymerizing monomeric methylmethacrylate in the presence of the antigen. As a comparison, influenza virus was added to previously polymerized polymethylmethacrylate particles. In animal experiments, the antibody response in mice and guinea pigs was measured. After polymerization in the presence of the antigen, the adjuvant effect was dependent on the methylmethacrylate concentration used, reaching an optimal concentration at 0.5%. This adjuvant preparation was considerably more effective than simple addition of virus to comparable polymethacrylate preparations or to aluminum hydroxide. The latter two adjuvants were approximately equivalent in effectiveness.

机译：提出了一种使用流感病毒作为抗原的新型佐剂。通过在抗原的存在下聚合单体甲基丙烯酸甲酯来生产新的佐剂。作为比较，将流感病毒添加到预先聚合的聚甲基丙烯酸甲酯颗粒中。在动物实验中，测量了小鼠和豚鼠的抗体反应。在抗原存在下聚合后，佐剂效果取决于所用的甲基丙烯酸甲酯的浓度，达到0.5％的最佳浓度。该佐剂制剂比简单地将病毒添加到可比的聚甲基丙烯酸酯制剂或氢氧化铝中要有效得多。后两种佐剂的功效大致相同。

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《Infection and immunity》 |1976年第1期|共7页
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J Kreuter; P P Speiser;
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中图分类医学免疫学;
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6. New adjuvants on a polymethylmethacrylate base. [O] . J Kreuter, P P Speiser 1976

机译：以聚甲基丙烯酸甲酯为基础的新助剂。
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New adjuvants on a polymethylmethacrylate base.

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