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首页> 外文期刊>Infection and immunity >Ultrastructural and biochemical alterations effected by viridin B, a bacterocin of alpha-hemolytic streptococci.
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Ultrastructural and biochemical alterations effected by viridin B, a bacterocin of alpha-hemolytic streptococci.

机译：超微结构和生化改变受病毒素B（一种α-溶血性链球菌的细菌素）的影响。

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Viridin B, a bacteriocin produced by Streptococcus mitis strain 42885, was shown previously to exert a bactericidal effect against a Neisseria sicca strain but only a bacteriostatic effect against a coagulase-negative staphylococcus. In the present report, this dual effect was defined further. Viridin B caused the appearance of mesosomes in both indicator strains early in the course of exposure. Whereas mesosomes were the only noticeable alterations in the staphylococcal strain at all times of exposure to bacteriocin, progressive changes occurred in the N. sicca cells involving the nucleoid and cytoplasmic contents and resulting in the appearance of bacterial ghosts. Biochemical studies indicated a rapid and complete cessation of the incorporation of [3H]thymidine in N. sicca and in the staphylococcus. Whereas the incorporation of [3H]leucine and [3H]uridine in N. sicca was completely stopped, such incorporation was only reduced in the staphylococcus.
机译：先前显示由病毒链球菌菌株42885产生的细菌素病毒素B对干燥的奈瑟氏球菌菌株具有杀菌作用，而对凝固酶阴性葡萄球菌仅具有抑菌作用。在本报告中，进一步定义了这种双重影响。在暴露过程的早期，Viridin B引起了这两种指示菌株中的微粒体的出现。在所有暴露于细菌素的情况下，均是微粒体在葡萄球菌菌株中的唯一显着变化，而在干燥的N. sicca细胞中发生了涉及核苷和细胞质含量的逐步变化，并导致了细菌幽灵的出现。生化研究表明，[3H]胸腺嘧啶核苷在干燥烟草和葡萄球菌中的掺入迅速完全停止。尽管[3H]亮氨酸和[3H]尿苷在干燥烟草中的掺入被完全停止，但是这种掺入仅在葡萄球菌中被减少。

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