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首页> 外文期刊>Infection and immunity >Comparative Behavior of Virulent Strains of Treponema pallidum and Treponema pertenue in Gradient Cultures of Various Mammalian Cells
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Comparative Behavior of Virulent Strains of Treponema pallidum and Treponema pertenue in Gradient Cultures of Various Mammalian Cells

机译：梅毒螺旋体和梅毒螺旋体的毒力菌株在各种哺乳动物细胞梯度培养中的比较行为

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Two strains of virulent Treponema pallidum and two of virulent T. pertenue were investigated for their ability to attach to and survive in gradient cultures of five different mammalian cells under aerobic conditions. The strains of T. pallidum studied were the high-rabbit-passage Nichols and the low-rabbit-passage KKJ. The former was known to readily attach to cottontail rabbit epithelial cells (Sf1Ep) and to survive in the virulent state for up to 21 days. We therefore compared attachment of the other virulent treponemes with that of T. pallidum (Nichols). The KKJ strain of T. pallidum behaved in a fashion similar to T. pallidum (Nichols) in all of the cultures. Both strains exhibited preferential attachment to cells of Sf1Ep and those derived from the ear of a nude athymic (nuu) mouse. In these cultures, we observed a consistent three- to fivefold increase in attached treponemes up to 12 days after initial inoculation. The strains of T. pertenue were the human-derived Gauthier and cynocephalus-derived FB. These two strains of T. pertenue also attached to cells of all five types of cultures, but in smaller numbers than were seen with T. pallidum and equally to all of the cultures. Neither preferential attachment to Sf1Ep and nude mouse ear cells nor increased attachment with time was seen.
机译：两种毒株梅毒螺旋体和两种毒株 T。在有氧条件下，研究了pertenue 在五个不同哺乳动物细胞的梯度培养物中附着和存活的能力。 T的菌株。研究的苍白球是高兔子通道的尼科尔斯和低兔子通道的KKJ。已知前者很容易附着在棉尾兔上皮细胞（Sf1Ep）上，并在强毒状态下存活长达21天。因此，我们比较了其他有毒的色氨酸和 T的色氨酸。 pallidum （尼科尔斯）。 T的KKJ株。苍白发的行为类似于 T。所有文化中都使用pallidum （Nichols）。两种菌株均显示优先附着于Sf1Ep细胞，以及源自裸胸腺（nu / nu）小鼠耳朵的细胞。在这些文化中，我们观察到初次接种后长达12天，附着的色氨酸持续增加三到五倍。 T的菌株。蠕虫是人类来源的高迪耶（Gauthier）和猕猴来源的FB。这两株 T。 pertenue 也附着在所有五种培养物的细胞上，但数量少于 T。苍白花以及所有文化既未发现对Sf1Ep和裸鼠耳朵细胞的优先附着，也没有发现随着时间的推移附着增加。

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